A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of Therapies
The value of combination therapy for refractory ITP is not well defined. We present the case of a 29-year-old male with severe ITP refractory to initial standard therapy including steroids, IVIG, and subsequent splenectomy, who was treated with the combination therapy of rituximab, romiplostim, and...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/8207017 |
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| _version_ | 1832561652795441152 |
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| author | Hanyin Wang Hande Tuncer |
| author_facet | Hanyin Wang Hande Tuncer |
| author_sort | Hanyin Wang |
| collection | DOAJ |
| description | The value of combination therapy for refractory ITP is not well defined. We present the case of a 29-year-old male with severe ITP refractory to initial standard therapy including steroids, IVIG, and subsequent splenectomy, who was treated with the combination therapy of rituximab, romiplostim, and mycophenolate and eventually developed thrombocytosis requiring plateletpheresis. Our case highlights the importance of the need to understand predictors of response to standard upfront treatment of acute ITP. |
| format | Article |
| id | doaj-art-9110d803c7984b4b89860233a02df0e0 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-9110d803c7984b4b89860233a02df0e02025-02-03T01:24:30ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/82070178207017A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of TherapiesHanyin Wang0Hande Tuncer1Department of Internal Medicine, Tufts Medical Center, 800 Washington St., Boston, MA 02111, USADivision of Hematology/Oncology, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USAThe value of combination therapy for refractory ITP is not well defined. We present the case of a 29-year-old male with severe ITP refractory to initial standard therapy including steroids, IVIG, and subsequent splenectomy, who was treated with the combination therapy of rituximab, romiplostim, and mycophenolate and eventually developed thrombocytosis requiring plateletpheresis. Our case highlights the importance of the need to understand predictors of response to standard upfront treatment of acute ITP.http://dx.doi.org/10.1155/2018/8207017 |
| spellingShingle | Hanyin Wang Hande Tuncer A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of Therapies Case Reports in Hematology |
| title | A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of Therapies |
| title_full | A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of Therapies |
| title_fullStr | A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of Therapies |
| title_full_unstemmed | A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of Therapies |
| title_short | A Case of Primary Refractory Immune Thrombocytopenia: Challenges in Choice of Therapies |
| title_sort | case of primary refractory immune thrombocytopenia challenges in choice of therapies |
| url | http://dx.doi.org/10.1155/2018/8207017 |
| work_keys_str_mv | AT hanyinwang acaseofprimaryrefractoryimmunethrombocytopeniachallengesinchoiceoftherapies AT handetuncer acaseofprimaryrefractoryimmunethrombocytopeniachallengesinchoiceoftherapies AT hanyinwang caseofprimaryrefractoryimmunethrombocytopeniachallengesinchoiceoftherapies AT handetuncer caseofprimaryrefractoryimmunethrombocytopeniachallengesinchoiceoftherapies |