Reconciling predicted and measured viscosity parameters in high concentration therapeutic antibody solutions

Reconciling predicted and measured viscosity parameters in high concentration therapeutic antibody solutions

Monoclonal antibody (mAb) solution viscosity in ultra-high concentration formulations is a key developability consideration in mAb development risk mitigation strategies that has implications for downstream processing and patient safety. Predicting viscosity at therapeutically relevant concentration...

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Bibliographic Details
Main Authors: Georgina Bethany Armstrong, Aisling Roche, William Lewis, Zahra Rattray
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Antibody
formulation
physicochemical descriptors
prediction
viscosity
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2438172
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