15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism
15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR-γ signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, an...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2019/7242030 |
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| author | Jingjing Li Chuanyong Guo Jianye Wu |
| author_facet | Jingjing Li Chuanyong Guo Jianye Wu |
| author_sort | Jingjing Li |
| collection | DOAJ |
| description | 15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR-γ signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects. Although many synthetic PPAR-γ receptor agonists have been developed, as an endogenous product of PPAR-γ receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism. In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-γ. It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases. |
| format | Article |
| id | doaj-art-91074f49930745a39650946ba0a197be |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-91074f49930745a39650946ba0a197be2025-02-03T05:50:48ZengWileyPPAR Research1687-47571687-47652019-01-01201910.1155/2019/7242030724203015-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and MechanismJingjing Li0Chuanyong Guo1Jianye Wu2Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, ChinaDepartment of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, ChinaDepartment of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR-γ signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects. Although many synthetic PPAR-γ receptor agonists have been developed, as an endogenous product of PPAR-γ receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism. In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-γ. It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases.http://dx.doi.org/10.1155/2019/7242030 |
| spellingShingle | Jingjing Li Chuanyong Guo Jianye Wu 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism PPAR Research |
| title | 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism |
| title_full | 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism |
| title_fullStr | 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism |
| title_full_unstemmed | 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism |
| title_short | 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism |
| title_sort | 15 deoxy ∆ 12 14 prostaglandin j2 15d pgj2 an endogenous ligand of ppar γ function and mechanism |
| url | http://dx.doi.org/10.1155/2019/7242030 |
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