Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction
Purpose. The aim of this study was to determine the efficacy of prophylactic antibiotics (PA) for reducing the infectious complications and the potential risk factors responsible for the infectious complications after stent insertion for malignant colorectal obstruction. Methods. We performed a retr...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/416142 |
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| author | Jong-Sun Kim Wan-Sik Lee Cho-Yun Chung Hyung-Chul Park Dae-Seong Myung Chan-Young Oak Mi-Young Kim Mi-Ok Jang Seung-Ji Kang Hee-Chang Jang Sung-Bum Cho Hyun-Soo Kim Young-Eun Joo |
| author_facet | Jong-Sun Kim Wan-Sik Lee Cho-Yun Chung Hyung-Chul Park Dae-Seong Myung Chan-Young Oak Mi-Young Kim Mi-Ok Jang Seung-Ji Kang Hee-Chang Jang Sung-Bum Cho Hyun-Soo Kim Young-Eun Joo |
| author_sort | Jong-Sun Kim |
| collection | DOAJ |
| description | Purpose. The aim of this study was to determine the efficacy of prophylactic antibiotics (PA) for reducing the infectious complications and the potential risk factors responsible for the infectious complications after stent insertion for malignant colorectal obstruction. Methods. We performed a retrospective review of 224 patients who underwent self-expandable metallic stent (SEMS) insertion for malignant colorectal obstruction from May 2004 to December 2012. Results. There were 145 patients in the PA group and 79 in non-PA group. The CRP level in PA group was significantly higher than that in non-PA. Abdominal tenderness and mechanical ileus were significantly more frequent in PA group than those in non-PA. The frequency of post-SEMS insertion fever, systemic inflammatory response syndrome (SIRS), and bacteremia was not significantly different between PA and non-PA groups. In multivariate analysis, the CRP level was risk factor related to post-SEMS insertion SIRS. However, in propensity score matching analysis, there was no independent risk factor related to post-SEMS insertion fever, SIRS, and bacteremia. Conclusion. The use of PA in patients with malignant colorectal obstruction may be not effective to prevent the development of infectious complications after SEMS insertion. |
| format | Article |
| id | doaj-art-9101281629cc4d74bf6f9a8ec3f2c1ee |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9101281629cc4d74bf6f9a8ec3f2c1ee2025-02-03T05:58:39ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/416142416142Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal ObstructionJong-Sun Kim0Wan-Sik Lee1Cho-Yun Chung2Hyung-Chul Park3Dae-Seong Myung4Chan-Young Oak5Mi-Young Kim6Mi-Ok Jang7Seung-Ji Kang8Hee-Chang Jang9Sung-Bum Cho10Hyun-Soo Kim11Young-Eun Joo12Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Infectious Diseases, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Infectious Diseases, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Infectious Diseases, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaPurpose. The aim of this study was to determine the efficacy of prophylactic antibiotics (PA) for reducing the infectious complications and the potential risk factors responsible for the infectious complications after stent insertion for malignant colorectal obstruction. Methods. We performed a retrospective review of 224 patients who underwent self-expandable metallic stent (SEMS) insertion for malignant colorectal obstruction from May 2004 to December 2012. Results. There were 145 patients in the PA group and 79 in non-PA group. The CRP level in PA group was significantly higher than that in non-PA. Abdominal tenderness and mechanical ileus were significantly more frequent in PA group than those in non-PA. The frequency of post-SEMS insertion fever, systemic inflammatory response syndrome (SIRS), and bacteremia was not significantly different between PA and non-PA groups. In multivariate analysis, the CRP level was risk factor related to post-SEMS insertion SIRS. However, in propensity score matching analysis, there was no independent risk factor related to post-SEMS insertion fever, SIRS, and bacteremia. Conclusion. The use of PA in patients with malignant colorectal obstruction may be not effective to prevent the development of infectious complications after SEMS insertion.http://dx.doi.org/10.1155/2015/416142 |
| spellingShingle | Jong-Sun Kim Wan-Sik Lee Cho-Yun Chung Hyung-Chul Park Dae-Seong Myung Chan-Young Oak Mi-Young Kim Mi-Ok Jang Seung-Ji Kang Hee-Chang Jang Sung-Bum Cho Hyun-Soo Kim Young-Eun Joo Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction Gastroenterology Research and Practice |
| title | Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction |
| title_full | Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction |
| title_fullStr | Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction |
| title_full_unstemmed | Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction |
| title_short | Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction |
| title_sort | clinical impact of prophylactic antibiotic treatment for self expandable metallic stent insertion in patients with malignant colorectal obstruction |
| url | http://dx.doi.org/10.1155/2015/416142 |
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