Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/8419104 |
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| _version_ | 1832556831446138880 |
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| author | Luca Genovese Andrea Brendolan |
| author_facet | Luca Genovese Andrea Brendolan |
| author_sort | Luca Genovese |
| collection | DOAJ |
| description | Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear. |
| format | Article |
| id | doaj-art-90fd7d614e524466ba1538ec5a8e88b7 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-90fd7d614e524466ba1538ec5a8e88b72025-02-03T05:44:14ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/84191048419104Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue RemodelingLuca Genovese0Andrea Brendolan1Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyDivision of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalySecondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.http://dx.doi.org/10.1155/2016/8419104 |
| spellingShingle | Luca Genovese Andrea Brendolan Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling Stem Cells International |
| title | Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling |
| title_full | Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling |
| title_fullStr | Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling |
| title_full_unstemmed | Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling |
| title_short | Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling |
| title_sort | lymphoid tissue mesenchymal stromal cells in development and tissue remodeling |
| url | http://dx.doi.org/10.1155/2016/8419104 |
| work_keys_str_mv | AT lucagenovese lymphoidtissuemesenchymalstromalcellsindevelopmentandtissueremodeling AT andreabrendolan lymphoidtissuemesenchymalstromalcellsindevelopmentandtissueremodeling |