From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes

From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes

ABSTRACT African swine fever virus (ASFV) is a high-consequence pathogen posing a substantial threat to global food security. This large DNA virus encodes more than 150 open reading frames, many of which are uncharacterized. The EP402R gene encodes CD2v, a glycoprotein expressed on the surface of in...

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Main Authors: Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
African swine fever virus
immune evasion
EP402R
virulence factors
persistence
erythrocyte adhesion
Online Access:https://journals.asm.org/doi/10.1128/mbio.01655-24
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