Concurrent hypoxia and apoptosis imparts immune programming potential in mesenchymal stem cells: Lesson from acute graft-versus-host-disease model

Concurrent hypoxia and apoptosis imparts immune programming potential in mesenchymal stem cells: Lesson from acute graft-versus-host-disease model

Abstract Background Mesenchymal stem cells (MSCs) have emerged as promising candidates for immune modulation in various diseases that are associated with dysregulated immune responses like Graft-versus-Host-Disease (GVHD). MSCs are pleiotropic and the fate of MSCs following administration is a major...

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Main Authors: Mohini Mendiratta, Meenakshi Mendiratta, Shuvadeep Ganguly, Sandeep Rai, Ritu Gupta, Lalit Kumar, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Prabhat Singh Malik, Raja Pramanik, Mukul Aggarwal, Aditya Kumar Gupta, Rishi Dhawan, Tulika Seth, Manoranjan Mahapatra, Baibaswata Nayak, Thoudam Debraj Singh, Sachin Kumar, Riyaz Ahmed Mir, Gurvinder Kaur, Hariprasad GuruRao, Mayank Singh, Chandra Prakash Prasad, Hridayesh Prakash, Sujata Mohanty, Ranjit Kumar Sahoo
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Apoptosis
Hypoxia
Immunomodulation
Acute graft-versus-host-disease
Wharton’s Jelly
Online Access:https://doi.org/10.1186/s13287-024-03947-2
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