The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study
Intestinal microbiota imbalance may worsen the progression of ulcerative colitis (UC). Lacticaseibacillus rhamnosus LS8 (LR) has the potential ability to regulate microbiota through producing a novel antibacterial substance, cyclic opine: cycloalanopine. This study aimed to investigate whether LR co...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250066 |
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| author | Tao Wang Shuang Wang Shuchen Dong Ruiling Wang Shuxuan Wang Jie Yang Xin Wang Xin Lü |
| author_facet | Tao Wang Shuang Wang Shuchen Dong Ruiling Wang Shuxuan Wang Jie Yang Xin Wang Xin Lü |
| author_sort | Tao Wang |
| collection | DOAJ |
| description | Intestinal microbiota imbalance may worsen the progression of ulcerative colitis (UC). Lacticaseibacillus rhamnosus LS8 (LR) has the potential ability to regulate microbiota through producing a novel antibacterial substance, cyclic opine: cycloalanopine. This study aimed to investigate whether LR could ameliorate dextran sulfate sodium-induced UC in mice via modulating intestinal microbiota using fecal microbiota transplantation (FMT) experiment. The results showed that both LR and FMT attenuated UC as evidenced by 1) alleviating disease activity index and colonic pathology; 2) up-regulating MUCs and tight junction proteins; 3) increasing oxidative mediators and decreasing antioxidant mediators; 4) down-regulating proinflammatory cytokines and chemokines. These results were mainly attributable to the microbiota-regulating effect of LR, including increasing benefi cial bacteria (like Akkermansia) and its related SCFAs, while decreasing harmful bacteria (like Proteobacteria) and its related LPS, thereby suppressing the hyperactivation of TLR4/NF-κB pathway. Consequently, LR can alleviate UC and is a potential dietary supplement to attenuate UC. |
| format | Article |
| id | doaj-art-90dffcae8d854a47bae30b3f6e978b8d |
| institution | DOAJ |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-90dffcae8d854a47bae30b3f6e978b8d2025-08-20T03:18:52ZengTsinghua University PressFood Science and Human Wellness2213-45302024-03-0113277879010.26599/FSHW.2022.9250066The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation studyTao Wang0Shuang Wang1Shuchen Dong2Ruiling Wang3Shuxuan Wang4Jie Yang5Xin Wang6Xin Lü7College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaSchool of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaIntestinal microbiota imbalance may worsen the progression of ulcerative colitis (UC). Lacticaseibacillus rhamnosus LS8 (LR) has the potential ability to regulate microbiota through producing a novel antibacterial substance, cyclic opine: cycloalanopine. This study aimed to investigate whether LR could ameliorate dextran sulfate sodium-induced UC in mice via modulating intestinal microbiota using fecal microbiota transplantation (FMT) experiment. The results showed that both LR and FMT attenuated UC as evidenced by 1) alleviating disease activity index and colonic pathology; 2) up-regulating MUCs and tight junction proteins; 3) increasing oxidative mediators and decreasing antioxidant mediators; 4) down-regulating proinflammatory cytokines and chemokines. These results were mainly attributable to the microbiota-regulating effect of LR, including increasing benefi cial bacteria (like Akkermansia) and its related SCFAs, while decreasing harmful bacteria (like Proteobacteria) and its related LPS, thereby suppressing the hyperactivation of TLR4/NF-κB pathway. Consequently, LR can alleviate UC and is a potential dietary supplement to attenuate UC.https://www.sciopen.com/article/10.26599/FSHW.2022.9250066gut barriergut microbiotafecal microbiota transplantationlacticaseibacillus rhamnosusoxidative stressulcerative colitis |
| spellingShingle | Tao Wang Shuang Wang Shuchen Dong Ruiling Wang Shuxuan Wang Jie Yang Xin Wang Xin Lü The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study Food Science and Human Wellness gut barrier gut microbiota fecal microbiota transplantation lacticaseibacillus rhamnosus oxidative stress ulcerative colitis |
| title | The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study |
| title_full | The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study |
| title_fullStr | The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study |
| title_full_unstemmed | The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study |
| title_short | The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study |
| title_sort | role of a novel antibacterial substance cyclic opine producing lacticaseibacillus rhamnosus ls8 in ameliorating ulcerative colitis a fecal microbiota transplantation study |
| topic | gut barrier gut microbiota fecal microbiota transplantation lacticaseibacillus rhamnosus oxidative stress ulcerative colitis |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250066 |
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