Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training
Changes in food reward have been implicated in exercise-induced compensatory eating behaviour. However, the underlying mechanisms of food reward, and the physiological correlates of exercise-induced changes in food reward, are unknown. Methods. Forty-six overweight and obese individuals completed 12...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/323728 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545726864818176 |
|---|---|
| author | Mark Hopkins Catherine Gibbons Phillipa Caudwell Dominic-Luc Webb Per M. Hellström Erik Näslund John E. Blundell Graham Finlayson |
| author_facet | Mark Hopkins Catherine Gibbons Phillipa Caudwell Dominic-Luc Webb Per M. Hellström Erik Näslund John E. Blundell Graham Finlayson |
| author_sort | Mark Hopkins |
| collection | DOAJ |
| description | Changes in food reward have been implicated in exercise-induced compensatory eating behaviour. However, the underlying mechanisms of food reward, and the physiological correlates of exercise-induced changes in food reward, are unknown. Methods. Forty-six overweight and obese individuals completed 12 weeks of aerobic exercise. Body composition, food intake, and fasting metabolic-related hormones were measured at baseline, week six, and postintervention. On separate days, the reward value of high-and-low-fat food (explicit liking and implicit wanting) was also assessed at baseline, week six, and postintervention. Results. Following the intervention, FM, FFM, and VO2peak improved significantly, while fasting leptin decreased. However, food intake or reward did not change significantly. Cross-sectional analyses indicated that FM (P=0.022) and FFM (P=0.046) were associated with explicit liking for high-fat food, but implicit wanting was associated with FM only (P=0.005). Fasting leptin was associated with liking (P=0.023) and wanting (P=0.021) for high-fat food. Furthermore, a greater exercise-induced decline in fasting leptin was associated with increased liking (P=0.018). Conclusion. These data indicate that food reward has a number of physiological correlates. In particular, fasting leptin appears to play an active role in mediating food reward during exercise-induced weight loss. |
| format | Article |
| id | doaj-art-90dfb30ab1294a4bbfe45e42ec231c0b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-90dfb30ab1294a4bbfe45e42ec231c0b2025-02-03T07:24:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/323728323728Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise TrainingMark Hopkins0Catherine Gibbons1Phillipa Caudwell2Dominic-Luc Webb3Per M. Hellström4Erik Näslund5John E. Blundell6Graham Finlayson7Academy of Sport and Physical Activity, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield S10 2BP, UKInstitute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UKInstitute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UKDepartment of Medical Sciences, Gastroenterology and Hepatology, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenDivision of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, SwedenInstitute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UKInstitute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UKChanges in food reward have been implicated in exercise-induced compensatory eating behaviour. However, the underlying mechanisms of food reward, and the physiological correlates of exercise-induced changes in food reward, are unknown. Methods. Forty-six overweight and obese individuals completed 12 weeks of aerobic exercise. Body composition, food intake, and fasting metabolic-related hormones were measured at baseline, week six, and postintervention. On separate days, the reward value of high-and-low-fat food (explicit liking and implicit wanting) was also assessed at baseline, week six, and postintervention. Results. Following the intervention, FM, FFM, and VO2peak improved significantly, while fasting leptin decreased. However, food intake or reward did not change significantly. Cross-sectional analyses indicated that FM (P=0.022) and FFM (P=0.046) were associated with explicit liking for high-fat food, but implicit wanting was associated with FM only (P=0.005). Fasting leptin was associated with liking (P=0.023) and wanting (P=0.021) for high-fat food. Furthermore, a greater exercise-induced decline in fasting leptin was associated with increased liking (P=0.018). Conclusion. These data indicate that food reward has a number of physiological correlates. In particular, fasting leptin appears to play an active role in mediating food reward during exercise-induced weight loss.http://dx.doi.org/10.1155/2014/323728 |
| spellingShingle | Mark Hopkins Catherine Gibbons Phillipa Caudwell Dominic-Luc Webb Per M. Hellström Erik Näslund John E. Blundell Graham Finlayson Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training International Journal of Endocrinology |
| title | Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training |
| title_full | Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training |
| title_fullStr | Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training |
| title_full_unstemmed | Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training |
| title_short | Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training |
| title_sort | fasting leptin is a metabolic determinant of food reward in overweight and obese individuals during chronic aerobic exercise training |
| url | http://dx.doi.org/10.1155/2014/323728 |
| work_keys_str_mv | AT markhopkins fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining AT catherinegibbons fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining AT phillipacaudwell fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining AT dominiclucwebb fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining AT permhellstrom fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining AT eriknaslund fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining AT johneblundell fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining AT grahamfinlayson fastingleptinisametabolicdeterminantoffoodrewardinoverweightandobeseindividualsduringchronicaerobicexercisetraining |