Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133?
Abstract Extracellular membrane vesicles (EVs) offer promising values in various medical fields, e.g., as biomarkers in liquid biopsies or as native (or bioengineered) biological nanocarriers in tissue engineering, regenerative medicine and cancer therapy. Based on their cellular origin EVs can vary...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03102-w |
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| _version_ | 1832571315704299520 |
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| author | Jana Karbanová Kristina Thamm Christine A. Fargeas Ilker A. Deniz Aurelio Lorico Denis Corbeil |
| author_facet | Jana Karbanová Kristina Thamm Christine A. Fargeas Ilker A. Deniz Aurelio Lorico Denis Corbeil |
| author_sort | Jana Karbanová |
| collection | DOAJ |
| description | Abstract Extracellular membrane vesicles (EVs) offer promising values in various medical fields, e.g., as biomarkers in liquid biopsies or as native (or bioengineered) biological nanocarriers in tissue engineering, regenerative medicine and cancer therapy. Based on their cellular origin EVs can vary considerably in composition and diameter. Cell biological studies on mammalian prominin-1, a cholesterol-binding membrane glycoprotein, have helped to reveal new donor membranes as sources of EVs. For instance, small EVs can originate from microvilli and primary cilia, while large EVs might be produced by transient structures such as retracting cellular extremities of cancer cells during the mitotic rounding process, and the midbody at the end of cytokinesis. Here, we will highlight the various subcellular origins of prominin-1+ EVs, also called prominosomes, and the potential mechanism(s) regulating their formation. We will further discuss the molecular and cellular characteristics of prominin-1, notably those that have a direct effect on the release of prominin-1+ EVs, a process that might be directly implicated in donor cell reprogramming of stem and cancer stem cells. Prominin-1+ EVs also mediate intercellular communication during embryonic development and adult homeostasis in healthy individuals, while disseminating biological information during diseases. Graphical abstract |
| format | Article |
| id | doaj-art-90df44a673d0474483f3a1e895b5616e |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-90df44a673d0474483f3a1e895b5616e2025-02-02T12:41:15ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123113910.1186/s12951-025-03102-wProminosomes - a particular class of extracellular vesicles containing prominin-1/CD133?Jana Karbanová0Kristina Thamm1Christine A. Fargeas2Ilker A. Deniz3Aurelio Lorico4Denis Corbeil5Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität DresdenBiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität DresdenBiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität DresdenBiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität DresdenCollege of Osteopathic Medicine, Touro University NevadaBiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität DresdenAbstract Extracellular membrane vesicles (EVs) offer promising values in various medical fields, e.g., as biomarkers in liquid biopsies or as native (or bioengineered) biological nanocarriers in tissue engineering, regenerative medicine and cancer therapy. Based on their cellular origin EVs can vary considerably in composition and diameter. Cell biological studies on mammalian prominin-1, a cholesterol-binding membrane glycoprotein, have helped to reveal new donor membranes as sources of EVs. For instance, small EVs can originate from microvilli and primary cilia, while large EVs might be produced by transient structures such as retracting cellular extremities of cancer cells during the mitotic rounding process, and the midbody at the end of cytokinesis. Here, we will highlight the various subcellular origins of prominin-1+ EVs, also called prominosomes, and the potential mechanism(s) regulating their formation. We will further discuss the molecular and cellular characteristics of prominin-1, notably those that have a direct effect on the release of prominin-1+ EVs, a process that might be directly implicated in donor cell reprogramming of stem and cancer stem cells. Prominin-1+ EVs also mediate intercellular communication during embryonic development and adult homeostasis in healthy individuals, while disseminating biological information during diseases. Graphical abstracthttps://doi.org/10.1186/s12951-025-03102-wCD133Cell signalingCiliumEctosomeExosomeIntercellular communication |
| spellingShingle | Jana Karbanová Kristina Thamm Christine A. Fargeas Ilker A. Deniz Aurelio Lorico Denis Corbeil Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? Journal of Nanobiotechnology CD133 Cell signaling Cilium Ectosome Exosome Intercellular communication |
| title | Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? |
| title_full | Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? |
| title_fullStr | Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? |
| title_full_unstemmed | Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? |
| title_short | Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? |
| title_sort | prominosomes a particular class of extracellular vesicles containing prominin 1 cd133 |
| topic | CD133 Cell signaling Cilium Ectosome Exosome Intercellular communication |
| url | https://doi.org/10.1186/s12951-025-03102-w |
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