Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment
The impacts of air pollution, local climate, and urbanization on human health have been well-documented in recent studies. In this study, we combined magnetic resonance imaging (MRI) brain analysis with a questionnaire survey on the local environment in 141 healthy middle-aged men and women. Our fin...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925000357 |
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| author | Keisuke Kokubun Kiyotaka Nemoto Toshiharu Ikaga Yoshinori Yamakawa |
| author_facet | Keisuke Kokubun Kiyotaka Nemoto Toshiharu Ikaga Yoshinori Yamakawa |
| author_sort | Keisuke Kokubun |
| collection | DOAJ |
| description | The impacts of air pollution, local climate, and urbanization on human health have been well-documented in recent studies. In this study, we combined magnetic resonance imaging (MRI) brain analysis with a questionnaire survey on the local environment in 141 healthy middle-aged men and women. Our findings reveal that a favorable environment is positively correlated with gray matter volume (GMV) in the frontal and occipital lobes, cerebellum, and whole brain, as well as with fractional anisotropy (FA) in the fornix (including the fornix stria terminalis), posterior thalamic radiation (PTR), sagittal stratum (SS), and whole brain. Among these, significant correlations between the local environment and whole-brain and cerebellar GMV, PTR, and SS FA remained after Bonferroni correction. Additionally, the positive relationship between the local environment and whole-brain GMV was further supported by principal component analysis (PCA). This is the first study to demonstrate that healthy adult brain structure, as indicated by GMV and FA values, can be influenced by the local environment. |
| format | Article |
| id | doaj-art-90dec8ae8f274f74a87483c49f25fb71 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-90dec8ae8f274f74a87483c49f25fb712025-02-02T05:26:51ZengElsevierNeuroImage1095-95722025-03-01308121033Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environmentKeisuke Kokubun0Kiyotaka Nemoto1Toshiharu Ikaga2Yoshinori Yamakawa3Open Innovation Institute, Kyoto University, Kyoto, Japan; Graduate School of Management, Kyoto University, Kyoto, Japan; Corresponding author.Department of Psychiatry, Institute of Medicine, University of Tsukuba, Tsukuba, JapanInstitute for Built Environment and Carbon Neutral for SDGs, Chiyoda, Tokyo, JapanOpen Innovation Institute, Kyoto University, Kyoto, Japan; Graduate School of Management, Kyoto University, Kyoto, Japan; Institute of Innovative Research, Tokyo Institute of Technology, Meguro, Tokyo, Japan; ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), Chiyoda, Tokyo, Japan; Office for Academic and Industrial Innovation, Kobe University, Kobe, Japan; Brain Impact, Kyoto, JapanThe impacts of air pollution, local climate, and urbanization on human health have been well-documented in recent studies. In this study, we combined magnetic resonance imaging (MRI) brain analysis with a questionnaire survey on the local environment in 141 healthy middle-aged men and women. Our findings reveal that a favorable environment is positively correlated with gray matter volume (GMV) in the frontal and occipital lobes, cerebellum, and whole brain, as well as with fractional anisotropy (FA) in the fornix (including the fornix stria terminalis), posterior thalamic radiation (PTR), sagittal stratum (SS), and whole brain. Among these, significant correlations between the local environment and whole-brain and cerebellar GMV, PTR, and SS FA remained after Bonferroni correction. Additionally, the positive relationship between the local environment and whole-brain GMV was further supported by principal component analysis (PCA). This is the first study to demonstrate that healthy adult brain structure, as indicated by GMV and FA values, can be influenced by the local environment.http://www.sciencedirect.com/science/article/pii/S1053811925000357FornixFractional anisotropyGray matter volumeWhole brainLocal environmentPosterior thalamic radiation |
| spellingShingle | Keisuke Kokubun Kiyotaka Nemoto Toshiharu Ikaga Yoshinori Yamakawa Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment NeuroImage Fornix Fractional anisotropy Gray matter volume Whole brain Local environment Posterior thalamic radiation |
| title | Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment |
| title_full | Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment |
| title_fullStr | Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment |
| title_full_unstemmed | Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment |
| title_short | Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment |
| title_sort | whole brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment |
| topic | Fornix Fractional anisotropy Gray matter volume Whole brain Local environment Posterior thalamic radiation |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925000357 |
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