Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients
Sudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. Serum metabolites were detected by liquid chromatography-mass spectro...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.982561/full |
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| author | Xiangsheng Wang Yan Gao Ruirui Jiang |
| author_facet | Xiangsheng Wang Yan Gao Ruirui Jiang |
| author_sort | Xiangsheng Wang |
| collection | DOAJ |
| description | Sudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. Serum metabolites were detected by liquid chromatography-mass spectrometry, and metabolic profiles were analyzed. All patients were followed up for 3 months and categorized into recovery and non-recovery groups. The distinctive metabolites were assessed between two groups, and their predictive values for hearing recovery were evaluated. Analysis results revealed that SSNHL patients exhibited significantly characteristic metabolite signatures compared to HCs. The top 10 differential metabolites were further analyzed, and most of them showed potential diagnostic values based on receiver operator characteristic (ROC) curves. Finally, 14 SSNHL patients were divided into the recovery group, and six patients were included in the non-recovery group. Twelve distinctive metabolites were observed between the two groups, and ROC curves demonstrated that N4-acetylcytidine, p-phenylenediamine, sphingosine, glycero-3-phosphocholine, and nonadecanoic acid presented good predictabilities in the hearing recovery. Multivariate analysis results demonstrated that serum N4-Acetylcytidine, sphingosine and nonadecanoic acid levels were associated with hearing recovery in SSNHL patients. Our results identified that SSNHL patients exhibited distinctive serum metabolomics signatures, and several serum biomarkers were proved to be potential in predicting hearing recovery. The discriminative metabolites might contribute to illustrating the mechanisms of SSNHL and provide possible clues for its treatments. |
| format | Article |
| id | doaj-art-90dd30b4f74a40dfb5eea53c309cc2ff |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-90dd30b4f74a40dfb5eea53c309cc2ff2025-02-05T11:07:07ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-09-01910.3389/fmolb.2022.982561982561Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patientsXiangsheng Wang0Yan Gao1Ruirui Jiang2Department of Otolaryngology-Head and Neck Surgery, Urumqi Maternal and Child Health Care Hospital, Urumqi, ChinaDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xin Jiang Medical University, Urumqi, ChinaDepartment of Pharmacy, The First People’s Hospital of Urumqi (Children’s Hospital), Urumqi, ChinaSudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. Serum metabolites were detected by liquid chromatography-mass spectrometry, and metabolic profiles were analyzed. All patients were followed up for 3 months and categorized into recovery and non-recovery groups. The distinctive metabolites were assessed between two groups, and their predictive values for hearing recovery were evaluated. Analysis results revealed that SSNHL patients exhibited significantly characteristic metabolite signatures compared to HCs. The top 10 differential metabolites were further analyzed, and most of them showed potential diagnostic values based on receiver operator characteristic (ROC) curves. Finally, 14 SSNHL patients were divided into the recovery group, and six patients were included in the non-recovery group. Twelve distinctive metabolites were observed between the two groups, and ROC curves demonstrated that N4-acetylcytidine, p-phenylenediamine, sphingosine, glycero-3-phosphocholine, and nonadecanoic acid presented good predictabilities in the hearing recovery. Multivariate analysis results demonstrated that serum N4-Acetylcytidine, sphingosine and nonadecanoic acid levels were associated with hearing recovery in SSNHL patients. Our results identified that SSNHL patients exhibited distinctive serum metabolomics signatures, and several serum biomarkers were proved to be potential in predicting hearing recovery. The discriminative metabolites might contribute to illustrating the mechanisms of SSNHL and provide possible clues for its treatments.https://www.frontiersin.org/articles/10.3389/fmolb.2022.982561/fullsudden sensorineural hearing losshearing recoverymetabolomicsmetabolitesbiomarker |
| spellingShingle | Xiangsheng Wang Yan Gao Ruirui Jiang Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients Frontiers in Molecular Biosciences sudden sensorineural hearing loss hearing recovery metabolomics metabolites biomarker |
| title | Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients |
| title_full | Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients |
| title_fullStr | Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients |
| title_full_unstemmed | Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients |
| title_short | Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients |
| title_sort | diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients |
| topic | sudden sensorineural hearing loss hearing recovery metabolomics metabolites biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.982561/full |
| work_keys_str_mv | AT xiangshengwang diagnosticandpredictivevaluesofserummetabolicprofilesinsuddensensorineuralhearinglosspatients AT yangao diagnosticandpredictivevaluesofserummetabolicprofilesinsuddensensorineuralhearinglosspatients AT ruiruijiang diagnosticandpredictivevaluesofserummetabolicprofilesinsuddensensorineuralhearinglosspatients |