Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease

Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease

Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-γ agonist, decreased cell proliferation, interstitial fibrosis, and inflammatio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao
Format:	Article
Language:	English
Published:	Wiley 2012-01-01
Series:	PPAR Research
Online Access:	http://dx.doi.org/10.1155/2012/695898
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease
by: Lauren G. Russell, et al.
Published: (2025-01-01)

Novel Mutation in the PKHD1 Gene Diagnosed Prenatally in a Fetus with Autosomal Recessive Polycystic Kidney Disease
by: Pankaj Thakur, et al.
Published: (2014-01-01)

Unilateral focal choroidal excavation in autosomal recessive bestrophinopathy
by: Neha Goel
Published: (2025-01-01)

An Unusual Cardiac Manifestation in Autosomal Dominant Polycystic Kidney Disease
by: Fausta Catapano, et al.
Published: (2012-01-01)

Autosomal Recessive Bestrophinopathy: Clinical and Genetic Characteristics of Twenty-Four Cases
by: Hassan Khojasteh, et al.
Published: (2021-01-01)

Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease
by: Jianshe Wei, et al.
Published: (2021-01-01)

Differential Expression of -Associated Genes in Autosomal Dominant Polycystic Kidney Disease
by: Yeon Joo Yook, et al.
Published: (2012-03-01)

Gut microbiota and kidney function in autosomal dominant polycystic kidney disease participants in Cameroon: a cross-sectional study
by: Inès Obolo Nwaga, et al.
Published: (2025-01-01)

Healthcare Resource Utilization and Costs Associated with Autosomal Dominant Polycystic Kidney Disease
by: Christopher M. Blanchette, et al.
Published: (2014-07-01)

Genetic Study In a Pakistani Family Reveals Autosomal Recessive Type of Artemis Deficiency
by: Saddaf Ayub, et al.
Published: (2025-01-01)

Nephrotic Syndrome and Idiopathic Membranous Nephropathy Associated with Autosomal-Dominant Polycystic Kidney Disease
by: Ramón Peces, et al.
Published: (2011-01-01)

Identification of TMPRSS3 as a Significant Contributor to Autosomal Recessive Hearing Loss in the Chinese Population
by: Xue Gao, et al.
Published: (2017-01-01)

Targeting TRPM3 as a potential therapeutic approach for autosomal dominant polycystic kidney disease
by: Hüseyin Gül, et al.
Published: (2025-02-01)

An 11-Year-Old Child with Autosomal Dominant Polycystic Kidney Disease Who Presented with Nephrolithiasis
by: Fatih Firinci, et al.
Published: (2012-01-01)

Research priorities for autosomal dominant polycystic kidney disease: a UK priority setting partnership
by: Tess Harris, et al.
Published: (2022-06-01)

Pathogenic Variants in the ABCA12 Gene Associated to Autosomal Recessive Congenital Ichthyosis: Report of an Attenuated Phenotype
by: Gabriela Mantilla Beltrán, et al.
Published: (2024-11-01)

Vici Syndrome: A Rare Autosomal Recessive Syndrome with Brain Anomalies, Cardiomyopathy, and Severe Intellectual Disability
by: R. Curtis Rogers, et al.
Published: (2011-01-01)

The APOA1 p.Leu202Arg variant potentially causes autosomal recessive cardiac amyloidosis
by: Shusuke Yagi, et al.
Published: (2024-08-01)

Increased Apoptosis and Proliferative Capacity are Early Events in Cyst Formation in Autosomal-Dominant, Polycystic Kidney Disease
by: Salwa Ibrahim
Published: (2007-01-01)

Marfan Syndrome and Autosomal Dominant Polycystic Kidney Disease: A Case of Rare Co-occurrence or Coincidence?
by: Arjun Sekar
Published: (2022-09-01)

Absence of mTOR Inhibitor Effect on Hepatic Cyst Growth: A Case Report of a Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease
by: L. Friedrich, et al.
Published: (2012-01-01)

Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss
by: Fengguo Zhang, et al.
Published: (2018-01-01)

Validation of a hypomorphic variant in CDK13 as the cause of CHDFIDD with autosomal recessive inheritance through determination of an episignature
by: Jan Fischer, et al.
Published: (2025-01-01)

Genetic investigation of patients with autosomal recessive ataxia and identification of two novel variants in the SQSTM1 and SYNE1 genes
by: Diana Mokhtari, et al.
Published: (2024-08-01)

Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement
by: Ibrahim Khalil, MBBS, et al.
Published: (2025-04-01)

A new atypical splice mutation in PKD2 leading to autosomal dominant polycystic kidney disease in a Chinese family
by: Junlin Zhang, et al.
Published: (2024-04-01)

Spot Versus 24-Hour Urine Osmolality Measurement in Autosomal Dominant Polycystic Kidney Disease: A Diagnostic Test Study
by: Ayub Akbari, et al.
Published: (2025-03-01)

Skeletal abnormalities caused by a Connexin43R239Q mutation in a mouse model for autosomal recessive craniometaphyseal dysplasia
by: Yasuyuki Fujii, et al.
Published: (2025-01-01)

Compound Heterozygous Mutations in TMC1 and MYO15A Are Associated with Autosomal Recessive Nonsyndromic Hearing Loss in Two Chinese Han Families
by: Pengcheng Xu, et al.
Published: (2020-01-01)

THE CHARACTERISTICS OF MIRNA BINDING SITES IN MRNA OF ZFHX3 GENE AND ITS ORTHOLOGS
by: A. М. Kondybayeva, et al.
Published: (2018-07-01)

Different orthology inference algorithms generate similar predicted orthogroups among Brassicaceae species
by: Irene T. Liao, et al.
Published: (2025-01-01)

Novel Homozygous TTI2 Variant Causing Autosomal Recessive Syndromic Intellectual Disability and Primary Microcephaly from Pakistan: A Case Report (Exome Report)
by: Zul Qarnain, et al.
Published: (2022-01-01)

Renal anemia and hyporesponsiveness to ESA for preservation of residual kidney function in patients undergoing peritoneal dialysis
by: Takahiro Imaizumi, et al.
Published: (2025-01-01)

The Polymorphism of the ACE Gene Affects Left Ventricular Hypertrophy and Causes Disturbances in Left Ventricular Systolic/Diastolic Function in Patients with Autosomal Dominant Polycystic Kidney Disease
by: Maria Wanic-Kossowska, et al.
Published: (2014-01-01)

In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay
by: Aurélie Louit, et al.
Published: (2023-01-01)

Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model
by: Yasunori Sato, et al.
Published: (2012-01-01)

Trajectory of human migration: insights from autosomal and non-autosomal variant clustering patterns
by: Samayeta Sarkar Tuli, et al.
Published: (2025-03-01)

Comparison of Predictive In Silico Tools on Missense Variants in GJB2, GJB6, and GJB3 Genes Associated with Autosomal Recessive Deafness 1A (DFNB1A)
by: Vera G. Pshennikova, et al.
Published: (2019-01-01)

ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics.
by: Michael D Stubenvoll, et al.
Published: (2016-09-01)

Global recession scenarios
by: Henning Vöpel
Published: (2020-04-01)