Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis
Background. Pregnant and breastfeeding women are at risk for folate deficiency. Folate supplementation has been shown to be associated with enhanced markers of folate status. However, dose-response analyses for adult women are still lacking. Objective. To assess the dose-response relationship betwee...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/470656 |
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| author | Cristiana Berti Katalin Fekete Carla Dullemeijer Monica Trovato Olga W. Souverein Adriënne Cavelaars Rosalie Dhonukshe-Rutten Maddalena Massari Tamás Decsi Pieter van't Veer Irene Cetin |
| author_facet | Cristiana Berti Katalin Fekete Carla Dullemeijer Monica Trovato Olga W. Souverein Adriënne Cavelaars Rosalie Dhonukshe-Rutten Maddalena Massari Tamás Decsi Pieter van't Veer Irene Cetin |
| author_sort | Cristiana Berti |
| collection | DOAJ |
| description | Background. Pregnant and breastfeeding women are at risk for folate deficiency. Folate supplementation has been shown to be associated with enhanced markers of folate status. However, dose-response analyses for adult women are still lacking. Objective. To assess the dose-response relationship between total folate intake (folic acid plus dietary folate) and markers of folate status (plasma/serum folate, red blood cell folate, and plasma homocysteine); to evaluate potential differences between women in childbearing age, pregnant and lactating women. Methods. Electronic literature searches were carried out on three databases until February 2010. The overall pooled regression coefficient (β) and SE(β) were calculated using meta-analysis on a double-log scale.
Results. The majority of data was based on nonpregnant, nonlactating women in childbearingage. The pooled estimate of the relationship between folate intake and serum/plasma folate was 0.56 (95% CI = 0.40–0.72, P<0.00001); that is, the doubling of folate intake increases the folate level in serum/plasma by 47%. For red blood cell folate, the pooled-effect estimate was 0.30 (95% CI = 0.22–0.38, P<0.00001), that is, +23% for doubling intake. For plasma-homocysteine it was –0.10 (95% = –0.17 to –0.04, P=0.001), that is, –7% for doubling the intake. Associations tended to be weaker in pregnant and lactating women. Conclusion. Significant relationships between folate intake and serum/plasma folate, red blood cell folate, and plasma homocysteine were quantified. This dose-response methodology may be applied for setting requirements for women in childbearing age, as well as for pregnant and lactating women. |
| format | Article |
| id | doaj-art-90d1ff2df00740f08ed8d08d0b5e7531 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-90d1ff2df00740f08ed8d08d0b5e75312025-02-03T01:23:26ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/470656470656Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-AnalysisCristiana Berti0Katalin Fekete1Carla Dullemeijer2Monica Trovato3Olga W. Souverein4Adriënne Cavelaars5Rosalie Dhonukshe-Rutten6Maddalena Massari7Tamás Decsi8Pieter van't Veer9Irene Cetin10Unit of Obstetrics and Gynecology, Department of Clinical Sciences Hospital ‘L. Sacco’ and Center for Fetal Research Giorgio Pardi, University of Milan, 20157 Milan, ItalyUniversity of Pécs, H-7623 Pécs, HungaryDivision of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsUnit of Obstetrics and Gynecology, Department of Clinical Sciences Hospital ‘L. Sacco’ and Center for Fetal Research Giorgio Pardi, University of Milan, 20157 Milan, ItalyDivision of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDivision of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDivision of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsUnit of Obstetrics and Gynecology, Department of Clinical Sciences Hospital ‘L. Sacco’ and Center for Fetal Research Giorgio Pardi, University of Milan, 20157 Milan, ItalyUniversity of Pécs, H-7623 Pécs, HungaryDivision of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsUnit of Obstetrics and Gynecology, Department of Clinical Sciences Hospital ‘L. Sacco’ and Center for Fetal Research Giorgio Pardi, University of Milan, 20157 Milan, ItalyBackground. Pregnant and breastfeeding women are at risk for folate deficiency. Folate supplementation has been shown to be associated with enhanced markers of folate status. However, dose-response analyses for adult women are still lacking. Objective. To assess the dose-response relationship between total folate intake (folic acid plus dietary folate) and markers of folate status (plasma/serum folate, red blood cell folate, and plasma homocysteine); to evaluate potential differences between women in childbearing age, pregnant and lactating women. Methods. Electronic literature searches were carried out on three databases until February 2010. The overall pooled regression coefficient (β) and SE(β) were calculated using meta-analysis on a double-log scale. Results. The majority of data was based on nonpregnant, nonlactating women in childbearingage. The pooled estimate of the relationship between folate intake and serum/plasma folate was 0.56 (95% CI = 0.40–0.72, P<0.00001); that is, the doubling of folate intake increases the folate level in serum/plasma by 47%. For red blood cell folate, the pooled-effect estimate was 0.30 (95% CI = 0.22–0.38, P<0.00001), that is, +23% for doubling intake. For plasma-homocysteine it was –0.10 (95% = –0.17 to –0.04, P=0.001), that is, –7% for doubling the intake. Associations tended to be weaker in pregnant and lactating women. Conclusion. Significant relationships between folate intake and serum/plasma folate, red blood cell folate, and plasma homocysteine were quantified. This dose-response methodology may be applied for setting requirements for women in childbearing age, as well as for pregnant and lactating women.http://dx.doi.org/10.1155/2012/470656 |
| spellingShingle | Cristiana Berti Katalin Fekete Carla Dullemeijer Monica Trovato Olga W. Souverein Adriënne Cavelaars Rosalie Dhonukshe-Rutten Maddalena Massari Tamás Decsi Pieter van't Veer Irene Cetin Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis Journal of Nutrition and Metabolism |
| title | Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis |
| title_full | Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis |
| title_fullStr | Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis |
| title_full_unstemmed | Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis |
| title_short | Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis |
| title_sort | folate intake and markers of folate status in women of reproductive age pregnant and lactating women a meta analysis |
| url | http://dx.doi.org/10.1155/2012/470656 |
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