Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep
Age-related cognitive impairments often include difficulty retrieving memories, particularly those that rely on executive control. In this paper we discuss the influence of the prefrontal cortex on memory retrieval, and the specific memory processes associated with the prefrontal cortex that decline...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/624795 |
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| author | Kristine A. Wilckens Kirk I. Erickson Mark E. Wheeler |
| author_facet | Kristine A. Wilckens Kirk I. Erickson Mark E. Wheeler |
| author_sort | Kristine A. Wilckens |
| collection | DOAJ |
| description | Age-related cognitive impairments often include difficulty retrieving memories, particularly those that rely on executive control. In this paper we discuss the influence of the prefrontal cortex on memory retrieval, and the specific memory processes associated with the prefrontal cortex that decline in late adulthood. We conclude that preretrieval processes associated with preparation to make a memory judgment are impaired, leading to greater reliance on postretrieval processes. This is consistent with the view that impairments in executive control significantly contribute to deficits in controlled retrieval. Finally, we discuss age-related changes in sleep as a potential mechanism that contributes to deficiencies in executive control that are important for efficient retrieval. The sleep literature points to the importance of slow-wave sleep in restoration of prefrontal cortex function. Given that slow-wave sleep significantly declines with age, we hypothesize that age-related changes in slow-wave sleep could mediate age-related decline in executive control, manifesting a robust deficit in controlled memory retrieval processes. Interventions, like physical activity, that improve sleep could be effective methods to enhance controlled memory processes in late life. |
| format | Article |
| id | doaj-art-90cde19f2f9c4f51be83ee85f9f91b71 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-90cde19f2f9c4f51be83ee85f9f91b712025-02-03T01:07:31ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/624795624795Age-Related Decline in Controlled Retrieval: The Role of the PFC and SleepKristine A. Wilckens0Kirk I. Erickson1Mark E. Wheeler2Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USADepartment of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USADepartment of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USAAge-related cognitive impairments often include difficulty retrieving memories, particularly those that rely on executive control. In this paper we discuss the influence of the prefrontal cortex on memory retrieval, and the specific memory processes associated with the prefrontal cortex that decline in late adulthood. We conclude that preretrieval processes associated with preparation to make a memory judgment are impaired, leading to greater reliance on postretrieval processes. This is consistent with the view that impairments in executive control significantly contribute to deficits in controlled retrieval. Finally, we discuss age-related changes in sleep as a potential mechanism that contributes to deficiencies in executive control that are important for efficient retrieval. The sleep literature points to the importance of slow-wave sleep in restoration of prefrontal cortex function. Given that slow-wave sleep significantly declines with age, we hypothesize that age-related changes in slow-wave sleep could mediate age-related decline in executive control, manifesting a robust deficit in controlled memory retrieval processes. Interventions, like physical activity, that improve sleep could be effective methods to enhance controlled memory processes in late life.http://dx.doi.org/10.1155/2012/624795 |
| spellingShingle | Kristine A. Wilckens Kirk I. Erickson Mark E. Wheeler Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep Neural Plasticity |
| title | Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep |
| title_full | Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep |
| title_fullStr | Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep |
| title_full_unstemmed | Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep |
| title_short | Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep |
| title_sort | age related decline in controlled retrieval the role of the pfc and sleep |
| url | http://dx.doi.org/10.1155/2012/624795 |
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