Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis
Host immune response against Mycobacterium tuberculosis is mediated by cellular immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the infection by mycobacteria, TNF-alpha seems to have a primordial function. This cytokine acts in synergy with IFN-gamma, st...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/745483 |
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| author | Yone Vila Nova Cavalcanti Maria Carolina Accioly Brelaz Juliana Kelle de Andrade Lemoine Neves José Candido Ferraz Valéria Rêgo Alves Pereira |
| author_facet | Yone Vila Nova Cavalcanti Maria Carolina Accioly Brelaz Juliana Kelle de Andrade Lemoine Neves José Candido Ferraz Valéria Rêgo Alves Pereira |
| author_sort | Yone Vila Nova Cavalcanti |
| collection | DOAJ |
| description | Host immune response against Mycobacterium tuberculosis is mediated by cellular immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the infection by mycobacteria, TNF-alpha seems to have a primordial function. This cytokine acts in synergy with IFN-gamma, stimulating the production of reactive nitrogen intermediates (RNIs), thus mediating the tuberculostatic function of macrophages, and also stimulating the migration of immune cells to the infection site, contributing to granuloma formation, which controls the disease progression. IFN-gamma is the main cytokine involved in the immune response against mycobacteria, and its major function is the activation of macrophages, allowing them to exert its microbicidal role functions. Different from TNF-alpha and IFN-gamma, IL-10 is considered primarily an inhibitory cytokine, important to an adequate balance between inflammatory and immunopathologic responses. The increase in IL-10 levels seems to support the survival of mycobacteria in the host. Although there is not yet conclusive studies concerning a clear dichotomy between Th1 and Th2 responses, involving protective immunity and susceptibility to the disease, respectively, we can suggest that the knowledge about this responses based on the prevailing cytokine profile can help to elucidate the immune response related to the protection against M. tuberculosis. |
| format | Article |
| id | doaj-art-90cb21881e1c41efaa84b0a0d91e9e37 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-90cb21881e1c41efaa84b0a0d91e9e372025-02-03T01:07:31ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/745483745483Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary TuberculosisYone Vila Nova Cavalcanti0Maria Carolina Accioly Brelaz1Juliana Kelle de Andrade Lemoine Neves2José Candido Ferraz3Valéria Rêgo Alves Pereira4Departamento de Biologia, UFRPE, Dom Manoel de Medeiros, S/N, Dois Irmãos, 52171-900 Recife, PE, BrazilDepartamento de Imunologia, Centro de Pesquisas Aggeu Magalhães (CPqAM/FIOCRUZ), Avenida Professor Moraes Rego S/N, Cidade Universitária, Campus da UFPE, 50670-420 Recife, PE, BrazilDepartamento de Imunologia, Centro de Pesquisas Aggeu Magalhães (CPqAM/FIOCRUZ), Avenida Professor Moraes Rego S/N, Cidade Universitária, Campus da UFPE, 50670-420 Recife, PE, BrazilNúcleo de Educação Física e Ciências do Esporte, Centro Acadêmico de Vitória, Universidade Federal de Pernanbuco (UFPE), Vitória de Santo Antão, PE, BrazilDepartamento de Imunologia, Centro de Pesquisas Aggeu Magalhães (CPqAM/FIOCRUZ), Avenida Professor Moraes Rego S/N, Cidade Universitária, Campus da UFPE, 50670-420 Recife, PE, BrazilHost immune response against Mycobacterium tuberculosis is mediated by cellular immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the infection by mycobacteria, TNF-alpha seems to have a primordial function. This cytokine acts in synergy with IFN-gamma, stimulating the production of reactive nitrogen intermediates (RNIs), thus mediating the tuberculostatic function of macrophages, and also stimulating the migration of immune cells to the infection site, contributing to granuloma formation, which controls the disease progression. IFN-gamma is the main cytokine involved in the immune response against mycobacteria, and its major function is the activation of macrophages, allowing them to exert its microbicidal role functions. Different from TNF-alpha and IFN-gamma, IL-10 is considered primarily an inhibitory cytokine, important to an adequate balance between inflammatory and immunopathologic responses. The increase in IL-10 levels seems to support the survival of mycobacteria in the host. Although there is not yet conclusive studies concerning a clear dichotomy between Th1 and Th2 responses, involving protective immunity and susceptibility to the disease, respectively, we can suggest that the knowledge about this responses based on the prevailing cytokine profile can help to elucidate the immune response related to the protection against M. tuberculosis.http://dx.doi.org/10.1155/2012/745483 |
| spellingShingle | Yone Vila Nova Cavalcanti Maria Carolina Accioly Brelaz Juliana Kelle de Andrade Lemoine Neves José Candido Ferraz Valéria Rêgo Alves Pereira Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis Pulmonary Medicine |
| title | Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis |
| title_full | Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis |
| title_fullStr | Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis |
| title_full_unstemmed | Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis |
| title_short | Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis |
| title_sort | role of tnf alpha ifn gamma and il 10 in the development of pulmonary tuberculosis |
| url | http://dx.doi.org/10.1155/2012/745483 |
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