The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway

The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway

Abstract The complex kinetics of disease-related amyloid aggregation of proteins such as α-Synuclein (α-Syn) in Parkinson’s disease and Aβ42 in Alzheimer’s disease include primary nucleation, amyloid fibril elongation and secondary nucleation. The latter can be a key accelerator of the aggregation p...

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Main Authors: Dhiman Ghosh, Felix Torres, Matthias M. Schneider, Dzmitry Ashkinadze, Harindranath Kadavath, Yanick Fleischmann, Simon Mergenthal, Peter Güntert, Georg Krainer, Ewa A. Andrzejewska, Lily Lin, Jiapeng Wei, Enrico Klotzsch, Tuomas Knowles, Roland Riek
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54212-2
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