Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis
<p>This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of <mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>CCl</m...
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| Format: | Article |
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| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/93253 |
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| Summary: | <p>This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of <mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>CCl</mml:mtext> </mml:mrow> <mml:mn>4</mml:mn> </mml:msub> </mml:mrow> </mml:math>, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-<mml:math> <mml:mi>α</mml:mi> </mml:math> mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-<mml:math> <mml:mi>α</mml:mi> </mml:math> mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-<mml:math> <mml:mi>α</mml:mi> </mml:math> signaling pathway to inhibit liver fibrosis.</p> |
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| ISSN: | 0962-9351 |