Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2
Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/289343 |
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| author | Aziz Alami Chentoufi Simon Gaudreau Alex Nguyen Mahmoud Sabha Abdelaziz Amrani Geyhad ElGhazali |
| author_facet | Aziz Alami Chentoufi Simon Gaudreau Alex Nguyen Mahmoud Sabha Abdelaziz Amrani Geyhad ElGhazali |
| author_sort | Aziz Alami Chentoufi |
| collection | DOAJ |
| description | Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. Gene knockout experiments in mouse models have shown a nonredundant activity of IL-2 related to its critical role in inducing nTreg and controlling peripheral T cell tolerance. Whereas strong evidence has suggested that IL-2 is critically required for nTreg-mediated T1D control, several fundamental questions remain to be addressed. In this paper, we highlight the recent findings and controversies regarding the tolerogenic properties of IL-2 mediated through nTreg. We further discuss a potential link between the immunomodulatory role of interleukin-2 and the pathogenesis of type 1 diabetes. |
| format | Article |
| id | doaj-art-90bf6a0a56d24ff0a9015c838b69b7fc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-90bf6a0a56d24ff0a9015c838b69b7fc2025-02-03T01:12:03ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/289343289343Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2Aziz Alami Chentoufi0Simon Gaudreau1Alex Nguyen2Mahmoud Sabha3Abdelaziz Amrani4Geyhad ElGhazali5Department of Immunology, Faculty of Medicine, King Fahad Medical City, Riyadh 11 525, P.O. Box 59046, Saudi ArabiaImmunology Division, Department of Paediatric, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, J1H 5N4, CanadaFaculty of Medicine, Touro University Nevada, Henderson, NV 89014, USAFaculty of Medicine, St. George's University, Bay Shore, NY 11706, USAImmunology Division, Department of Paediatric, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, J1H 5N4, CanadaDepartment of Immunology, Faculty of Medicine, King Fahad Medical City, Riyadh 11 525, P.O. Box 59046, Saudi ArabiaType 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. Gene knockout experiments in mouse models have shown a nonredundant activity of IL-2 related to its critical role in inducing nTreg and controlling peripheral T cell tolerance. Whereas strong evidence has suggested that IL-2 is critically required for nTreg-mediated T1D control, several fundamental questions remain to be addressed. In this paper, we highlight the recent findings and controversies regarding the tolerogenic properties of IL-2 mediated through nTreg. We further discuss a potential link between the immunomodulatory role of interleukin-2 and the pathogenesis of type 1 diabetes.http://dx.doi.org/10.1155/2011/289343 |
| spellingShingle | Aziz Alami Chentoufi Simon Gaudreau Alex Nguyen Mahmoud Sabha Abdelaziz Amrani Geyhad ElGhazali Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 Clinical and Developmental Immunology |
| title | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
| title_full | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
| title_fullStr | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
| title_full_unstemmed | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
| title_short | Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 |
| title_sort | type i diabetes associated tolerogenic properties of interleukin 2 |
| url | http://dx.doi.org/10.1155/2011/289343 |
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