How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and target...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2148129 |
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| author | Muhammad Babar Khawar Fareeha Azam Nadeem Sheikh Khawaja Abdul Mujeeb |
| author_facet | Muhammad Babar Khawar Fareeha Azam Nadeem Sheikh Khawaja Abdul Mujeeb |
| author_sort | Muhammad Babar Khawar |
| collection | DOAJ |
| description | Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and targets a number of body tissues including liver, pancreas, and other epithelial tissues. It provokes a series of downstream signaling pathways upon binding with IL-22R complex which protects liver damage through STAT3 activation. IL-22BP is an inhibitor of IL-22 which has 20–1000x more affinity to bind with IL-22 compared to IL-22R1 that inhibits IL-22 activity. Its level was found to be positively correlated with the severity of liver damage and fibrosis. So, the present review is an effort to reveal the exact mechanism lying in the hepatoprotective activity of IL-22 and some of its future therapeutic implications. |
| format | Article |
| id | doaj-art-90ba08fe5cd046a69060abd195e9d17a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-90ba08fe5cd046a69060abd195e9d17a2025-02-03T01:25:54ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/21481292148129How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?Muhammad Babar Khawar0Fareeha Azam1Nadeem Sheikh2Khawaja Abdul Mujeeb3Cell & Molecular Biology Lab, Department of Zoology, University of the Punjab, Lahore, PakistanCell & Molecular Biology Lab, Department of Zoology, University of the Punjab, Lahore, PakistanCell & Molecular Biology Lab, Department of Zoology, University of the Punjab, Lahore, PakistanCentennial College, Scarborough, Toronto, ON, CanadaInterleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and targets a number of body tissues including liver, pancreas, and other epithelial tissues. It provokes a series of downstream signaling pathways upon binding with IL-22R complex which protects liver damage through STAT3 activation. IL-22BP is an inhibitor of IL-22 which has 20–1000x more affinity to bind with IL-22 compared to IL-22R1 that inhibits IL-22 activity. Its level was found to be positively correlated with the severity of liver damage and fibrosis. So, the present review is an effort to reveal the exact mechanism lying in the hepatoprotective activity of IL-22 and some of its future therapeutic implications.http://dx.doi.org/10.1155/2016/2148129 |
| spellingShingle | Muhammad Babar Khawar Fareeha Azam Nadeem Sheikh Khawaja Abdul Mujeeb How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? Journal of Immunology Research |
| title | How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? |
| title_full | How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? |
| title_fullStr | How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? |
| title_full_unstemmed | How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? |
| title_short | How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? |
| title_sort | how does interleukin 22 mediate liver regeneration and prevent injury and fibrosis |
| url | http://dx.doi.org/10.1155/2016/2148129 |
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