Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems
DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination rep...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/179594 |
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| author | Rihito Morita Shuhei Nakane Atsuhiro Shimada Masao Inoue Hitoshi Iino Taisuke Wakamatsu Kenji Fukui Noriko Nakagawa Ryoji Masui Seiki Kuramitsu |
| author_facet | Rihito Morita Shuhei Nakane Atsuhiro Shimada Masao Inoue Hitoshi Iino Taisuke Wakamatsu Kenji Fukui Noriko Nakagawa Ryoji Masui Seiki Kuramitsu |
| author_sort | Rihito Morita |
| collection | DOAJ |
| description | DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways. Recent studies of the fundamental mechanisms for DNA repair processes have revealed a complexity beyond that initially expected, with inter- and intrapathway complementation as well as functional interactions between proteins involved in repair pathways. In this paper we give a broad overview of the whole DNA repair system and focus on the molecular basis of the repair machineries, particularly in Thermus thermophilus HB8. |
| format | Article |
| id | doaj-art-90b4101dbbbb49a3883e71b9b2888b93 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-90b4101dbbbb49a3883e71b9b2888b932025-02-03T01:24:20ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/179594179594Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic SystemsRihito Morita0Shuhei Nakane1Atsuhiro Shimada2Masao Inoue3Hitoshi Iino4Taisuke Wakamatsu5Kenji Fukui6Noriko Nakagawa7Ryoji Masui8Seiki Kuramitsu9Department of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanDepartment of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanDepartment of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanDepartment of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanDepartment of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanGraduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, JapanRIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, JapanDepartment of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanDepartment of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanDepartment of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanDNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways. Recent studies of the fundamental mechanisms for DNA repair processes have revealed a complexity beyond that initially expected, with inter- and intrapathway complementation as well as functional interactions between proteins involved in repair pathways. In this paper we give a broad overview of the whole DNA repair system and focus on the molecular basis of the repair machineries, particularly in Thermus thermophilus HB8.http://dx.doi.org/10.4061/2010/179594 |
| spellingShingle | Rihito Morita Shuhei Nakane Atsuhiro Shimada Masao Inoue Hitoshi Iino Taisuke Wakamatsu Kenji Fukui Noriko Nakagawa Ryoji Masui Seiki Kuramitsu Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems Journal of Nucleic Acids |
| title | Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems |
| title_full | Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems |
| title_fullStr | Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems |
| title_full_unstemmed | Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems |
| title_short | Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems |
| title_sort | molecular mechanisms of the whole dna repair system a comparison of bacterial and eukaryotic systems |
| url | http://dx.doi.org/10.4061/2010/179594 |
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