Single Tri-Epitopic Antibodies (TeAbs) to Botulinum Neurotoxin Serotypes B, E, and F Recapitulate the Full Potency of a Combination of Three Monoclonal Antibodies in Toxin Neutralization

Single Tri-Epitopic Antibodies (TeAbs) to Botulinum Neurotoxin Serotypes B, E, and F Recapitulate the Full Potency of a Combination of Three Monoclonal Antibodies in Toxin Neutralization

Recombinant monoclonal antibody (mAb) botulinum neurotoxin (BoNT) antitoxins, consisting of three mAbs that bind non-overlapping epitopes, are highly potent. However, the three-mAb mixtures pose unique development and manufacturing challenges. Combining even more mAbs to create multivalent antitoxin...

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Bibliographic Details
Main Authors: Jianlong Lou, Wei Hua Wen, Fraser Conrad, Christina C. Tam, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Toxins
Subjects:
tri-epitopic antibody
recombinant monoclonal antibody
botulinum neurotoxin
antitoxin
botulism
serotypes B, E, F
Online Access:https://www.mdpi.com/2072-6651/17/6/281
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