Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica
Diabetes mellitus is a global health problem requiring innovative approaches for effective management. Natural compounds derived from medicinal plants offer promising avenues due to their diverse biological activities. The aim of this study was to assess the inhibitory effects of Cedrus atlantica ex...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-01-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2024-0121 |
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| author | Idrissi Amine Mounadi Mahraz Mohamed Adil Drioua Soufiane Assouguem Amine Ali Essam A. Ibrahim Mohamed A. Mehta Chandra Mohan Lahlali Rachid Tlemcani Sara Moussaoui Fatima En-nabety Ghizlan Eloutassi Noureddine Lahkimi Amal |
| author_facet | Idrissi Amine Mounadi Mahraz Mohamed Adil Drioua Soufiane Assouguem Amine Ali Essam A. Ibrahim Mohamed A. Mehta Chandra Mohan Lahlali Rachid Tlemcani Sara Moussaoui Fatima En-nabety Ghizlan Eloutassi Noureddine Lahkimi Amal |
| author_sort | Idrissi Amine Mounadi |
| collection | DOAJ |
| description | Diabetes mellitus is a global health problem requiring innovative approaches for effective management. Natural compounds derived from medicinal plants offer promising avenues due to their diverse biological activities. The aim of this study was to assess the inhibitory effects of Cedrus atlantica extracts on the enzymes α-amylase and α-glucosidase, which play a crucial role in the regulation of postprandial glucose levels, as well as to investigate their phytochemical composition and antioxidant capabilities. Aqueous extract of bark (EA), aqueous extract of cones (CA), and aqueous extract of leaves (FA) of C. atlántica were prepared and evaluated for enzyme inhibition using acarbose as a standard. The CA extract showed potent α-amylase inhibition (IC50 307 ± 0.02 μg/mL) and remarkable α-glucosidase inhibition (IC50 70 ± 0.04 μg/mL), outperforming the FA and EA extracts. Quantitative analysis revealed that EA and CA extracts had higher total phenolic content, flavonoid content, and tannin content than FA extract. Antioxidant assessments highlighted the outstanding performance of CA extract, with a low IC50 ABTS (30.65 ± 0.1 μg/mL) and an impressive EC50 FRAP (59.43 ± 1.19 μg/mL), outperforming FA extract. The results demonstrate the remarkable antidiabetic potential of C. atlantica extracts, particularly the CA extract, by inhibiting key enzymes involved in carbohydrate digestion. These extracts possess various phytochemical compounds with significant antioxidant capacities, suggesting that they are suitable for pharmaceutical, nutraceutical, and cosmetic applications. Further research to isolate and identify the bioactive compounds in CA extract could lead to new therapeutic strategies for managing diabetes and oxidative stress-related conditions. |
| format | Article |
| id | doaj-art-90974ba32e244161b6b3a58f1621c62c |
| institution | Kabale University |
| issn | 2391-5420 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj-art-90974ba32e244161b6b3a58f1621c62c2025-01-20T11:08:20ZengDe GruyterOpen Chemistry2391-54202025-01-01231354510.1515/chem-2024-0121Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlanticaIdrissi Amine Mounadi0Mahraz Mohamed Adil1Drioua Soufiane2Assouguem Amine3Ali Essam A.4Ibrahim Mohamed A.5Mehta Chandra Mohan6Lahlali Rachid7Tlemcani Sara8Moussaoui Fatima9En-nabety Ghizlan10Eloutassi Noureddine11Lahkimi Amal12Laboratory of Engineering, Electrochemistry, Modelization and Environment, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdallah University, Fez, 30000, MoroccoLaboratory of Engineering, Electrochemistry, Modelization and Environment, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdallah University, Fez, 30000, MoroccoLaboratory of Analytical Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, MoroccoEthnopharmacology and Pharmacognosy Team, Faculty of Sciences and Technology, Errachidia, Moulay Ismaïl University, Meknes, MoroccoDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi ArabiaSchool of Agriculture, Lovely Professional University, Phagwara, Punjab, IndiaDepartment of Plant Protection and Environment, National School of Agriculture, Meknes, MoroccoLaboratory of Environmental Biotechnology, Agri-food, Health, Faculty of Sciences, Sidi Mohamed Ben Abdellah University, Fez, MoroccoDepartment of Tourism and Culinary Management, Faculty of Economics, University of Food Technologies, Plovdiv, BulgariaLaboratory of Engineering, Electrochemistry, Modelization and Environment, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdallah University, Fez, 30000, MoroccoLaboratory of Engineering, Electrochemistry, Modelization and Environment, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdallah University, Fez, 30000, MoroccoLaboratory of Engineering, Electrochemistry, Modelization and Environment, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdallah University, Fez, 30000, MoroccoDiabetes mellitus is a global health problem requiring innovative approaches for effective management. Natural compounds derived from medicinal plants offer promising avenues due to their diverse biological activities. The aim of this study was to assess the inhibitory effects of Cedrus atlantica extracts on the enzymes α-amylase and α-glucosidase, which play a crucial role in the regulation of postprandial glucose levels, as well as to investigate their phytochemical composition and antioxidant capabilities. Aqueous extract of bark (EA), aqueous extract of cones (CA), and aqueous extract of leaves (FA) of C. atlántica were prepared and evaluated for enzyme inhibition using acarbose as a standard. The CA extract showed potent α-amylase inhibition (IC50 307 ± 0.02 μg/mL) and remarkable α-glucosidase inhibition (IC50 70 ± 0.04 μg/mL), outperforming the FA and EA extracts. Quantitative analysis revealed that EA and CA extracts had higher total phenolic content, flavonoid content, and tannin content than FA extract. Antioxidant assessments highlighted the outstanding performance of CA extract, with a low IC50 ABTS (30.65 ± 0.1 μg/mL) and an impressive EC50 FRAP (59.43 ± 1.19 μg/mL), outperforming FA extract. The results demonstrate the remarkable antidiabetic potential of C. atlantica extracts, particularly the CA extract, by inhibiting key enzymes involved in carbohydrate digestion. These extracts possess various phytochemical compounds with significant antioxidant capacities, suggesting that they are suitable for pharmaceutical, nutraceutical, and cosmetic applications. Further research to isolate and identify the bioactive compounds in CA extract could lead to new therapeutic strategies for managing diabetes and oxidative stress-related conditions.https://doi.org/10.1515/chem-2024-0121antidiabetic activityantioxidant activityatlas cedarphytochemical |
| spellingShingle | Idrissi Amine Mounadi Mahraz Mohamed Adil Drioua Soufiane Assouguem Amine Ali Essam A. Ibrahim Mohamed A. Mehta Chandra Mohan Lahlali Rachid Tlemcani Sara Moussaoui Fatima En-nabety Ghizlan Eloutassi Noureddine Lahkimi Amal Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica Open Chemistry antidiabetic activity antioxidant activity atlas cedar phytochemical |
| title | Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica |
| title_full | Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica |
| title_fullStr | Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica |
| title_full_unstemmed | Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica |
| title_short | Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica |
| title_sort | phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of cedrus atlantica |
| topic | antidiabetic activity antioxidant activity atlas cedar phytochemical |
| url | https://doi.org/10.1515/chem-2024-0121 |
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