Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing
Neurons are polarized functional units. The somatodendritic compartment receives and integrates synaptic inputs while the axon relays relevant synaptic information in form of action potentials (APs) across long distance. Despite this well accepted notion, recent research has shown that, under certai...
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/608141 |
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| author | Barbara Imbrosci Angela Neitz Thomas Mittmann |
| author_facet | Barbara Imbrosci Angela Neitz Thomas Mittmann |
| author_sort | Barbara Imbrosci |
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| description | Neurons are polarized functional units. The somatodendritic compartment receives and integrates synaptic inputs while the axon relays relevant synaptic information in form of action potentials (APs) across long distance. Despite this well accepted notion, recent research has shown that, under certain circumstances, the axon can also generate APs independent of synaptic inputs at axonal sites distal from the soma. These ectopic APs travel both toward synaptic terminals and antidromically toward the soma. This unusual form of neuronal communication seems to preferentially occur in cortical inhibitory interneurons following a period of intense neuronal activity and might have profound implications for neuronal information processing. Here we show that trains of ectopically generated APs can be induced in a large portion of neocortical layer 2/3 GABAergic interneurons following a somatic depolarization inducing hundreds of APs. Sparsely occurring ectopic spikes were also observed in a large portion of layer 1 interneurons even in absence of prior somatic depolarization. Remarkably, we found that interneurons which produce ectopic APs display specific membrane and morphological properties significantly different from the remaining GABAergic cells and may therefore represent a functionally unique interneuronal subpopulation. |
| format | Article |
| id | doaj-art-90814ef71bec405b95cbb34d345f30d1 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-90814ef71bec405b95cbb34d345f30d12025-02-03T01:20:25ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/608141608141Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent FiringBarbara Imbrosci0Angela Neitz1Thomas Mittmann2Institute of Physiology, University Medical Center of the Johannes-Gutenberg University Mainz, 55128 Mainz, GermanyInstitute of Physiology, University Medical Center of the Johannes-Gutenberg University Mainz, 55128 Mainz, GermanyInstitute of Physiology, University Medical Center of the Johannes-Gutenberg University Mainz, 55128 Mainz, GermanyNeurons are polarized functional units. The somatodendritic compartment receives and integrates synaptic inputs while the axon relays relevant synaptic information in form of action potentials (APs) across long distance. Despite this well accepted notion, recent research has shown that, under certain circumstances, the axon can also generate APs independent of synaptic inputs at axonal sites distal from the soma. These ectopic APs travel both toward synaptic terminals and antidromically toward the soma. This unusual form of neuronal communication seems to preferentially occur in cortical inhibitory interneurons following a period of intense neuronal activity and might have profound implications for neuronal information processing. Here we show that trains of ectopically generated APs can be induced in a large portion of neocortical layer 2/3 GABAergic interneurons following a somatic depolarization inducing hundreds of APs. Sparsely occurring ectopic spikes were also observed in a large portion of layer 1 interneurons even in absence of prior somatic depolarization. Remarkably, we found that interneurons which produce ectopic APs display specific membrane and morphological properties significantly different from the remaining GABAergic cells and may therefore represent a functionally unique interneuronal subpopulation.http://dx.doi.org/10.1155/2015/608141 |
| spellingShingle | Barbara Imbrosci Angela Neitz Thomas Mittmann Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing Neural Plasticity |
| title | Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing |
| title_full | Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing |
| title_fullStr | Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing |
| title_full_unstemmed | Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing |
| title_short | Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing |
| title_sort | physiological properties of supragranular cortical inhibitory interneurons expressing retrograde persistent firing |
| url | http://dx.doi.org/10.1155/2015/608141 |
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