Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance
Abstract Drug resistance is a common challenge in clinical tumor treatment. A reduction in drug sensitivity of tumor cells is often accompanied by an increase in autophagy levels, leading to autophagy-related resistance. The effectiveness of combining chemotherapy drugs with autophagy inducers/inhib...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-024-02217-2 |
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| author | Peng Zhao Shuangshuang Yin Yuling Qiu Changgang Sun Haiyang Yu |
| author_facet | Peng Zhao Shuangshuang Yin Yuling Qiu Changgang Sun Haiyang Yu |
| author_sort | Peng Zhao |
| collection | DOAJ |
| description | Abstract Drug resistance is a common challenge in clinical tumor treatment. A reduction in drug sensitivity of tumor cells is often accompanied by an increase in autophagy levels, leading to autophagy-related resistance. The effectiveness of combining chemotherapy drugs with autophagy inducers/inhibitors has been widely confirmed, but the mechanisms are still unclear. Ferroptosis and pyroptosis can be affected by various types of autophagy. Therefore, ferroptosis and pyroptosis have crosstalk via autophagy, potentially leading to a switch in cell death types under certain conditions. As two forms of inflammatory programmed cell death, ferroptosis and pyroptosis have different effects on inflammation, and the cGAS-STING signaling pathway is also involved. Therefore, it also plays an important role in the progression of some chronic inflammatory diseases. This review discusses the relationship between autophagy, ferroptosis and pyroptosis, and attempts to uncover the reasons behind the evasion of tumor cell death and the nature of drug resistance. |
| format | Article |
| id | doaj-art-907b9c39081b4c34931c30cab7030f2a |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-907b9c39081b4c34931c30cab7030f2a2025-01-19T12:12:38ZengBMCMolecular Cancer1476-45982025-01-0124112410.1186/s12943-024-02217-2Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistancePeng Zhao0Shuangshuang Yin1Yuling Qiu2Changgang Sun3Haiyang Yu4National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese MedicineNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese MedicineTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical UniversityCollege of Traditional Chinese Medicine, Shandong Second Medical UniversityNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese MedicineAbstract Drug resistance is a common challenge in clinical tumor treatment. A reduction in drug sensitivity of tumor cells is often accompanied by an increase in autophagy levels, leading to autophagy-related resistance. The effectiveness of combining chemotherapy drugs with autophagy inducers/inhibitors has been widely confirmed, but the mechanisms are still unclear. Ferroptosis and pyroptosis can be affected by various types of autophagy. Therefore, ferroptosis and pyroptosis have crosstalk via autophagy, potentially leading to a switch in cell death types under certain conditions. As two forms of inflammatory programmed cell death, ferroptosis and pyroptosis have different effects on inflammation, and the cGAS-STING signaling pathway is also involved. Therefore, it also plays an important role in the progression of some chronic inflammatory diseases. This review discusses the relationship between autophagy, ferroptosis and pyroptosis, and attempts to uncover the reasons behind the evasion of tumor cell death and the nature of drug resistance.https://doi.org/10.1186/s12943-024-02217-2AutophagyFerroptosisPyroptosisFerritinophagyMitophagyCMA |
| spellingShingle | Peng Zhao Shuangshuang Yin Yuling Qiu Changgang Sun Haiyang Yu Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance Molecular Cancer Autophagy Ferroptosis Pyroptosis Ferritinophagy Mitophagy CMA |
| title | Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance |
| title_full | Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance |
| title_fullStr | Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance |
| title_full_unstemmed | Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance |
| title_short | Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance |
| title_sort | ferroptosis and pyroptosis are connected through autophagy a new perspective of overcoming drug resistance |
| topic | Autophagy Ferroptosis Pyroptosis Ferritinophagy Mitophagy CMA |
| url | https://doi.org/10.1186/s12943-024-02217-2 |
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