Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews
Objective. To dissect the efficacy of Tol-DC therapy with or without IS in multiple animal models of transplantation. Methods and Results. PubMed, Medline, Embase, and the Cochrane Library were searched for reviews published up to April 2015. Six systematic reviews and a total of 61 articles were fi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5730674 |
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| _version_ | 1850212900824678400 |
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| author | Yanni Zhou Juan Shan Yingjia Guo Shengfu Li Dan Long Youping Li Li Feng |
| author_facet | Yanni Zhou Juan Shan Yingjia Guo Shengfu Li Dan Long Youping Li Li Feng |
| author_sort | Yanni Zhou |
| collection | DOAJ |
| description | Objective. To dissect the efficacy of Tol-DC therapy with or without IS in multiple animal models of transplantation. Methods and Results. PubMed, Medline, Embase, and the Cochrane Library were searched for reviews published up to April 2015. Six systematic reviews and a total of 61 articles were finally included. Data were grouped by organ transplantation models and applied to meta-analysis. Our meta-analysis shows that Tol-DC therapy successfully prolonged allograft survival to varying extents in all except the islet transplantation models and with IS drugs further prolonged the survival of heart, skin, and islet allografts in mice, but not of heart allografts in rats. Compared with IS drugs alone, Tol-DC therapy with IS extended islet allograft survival in rats but failed to influence the survival of skin, small intestine, and heart allografts in rats or of heart and skin allografts in mice. Conclusion. Tol-DC therapy significantly prolonged multiple allograft survival and further prolonged survival with IS. However, standardized protocols for modification of Tol-DC should be established before its application in clinic. |
| format | Article |
| id | doaj-art-90790c9416d4470d9f9de8ed1a01a1c6 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-90790c9416d4470d9f9de8ed1a01a1c62025-08-20T02:09:14ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/57306745730674Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic ReviewsYanni Zhou0Juan Shan1Yingjia Guo2Shengfu Li3Dan Long4Youping Li5Li Feng6Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, ChinaObjective. To dissect the efficacy of Tol-DC therapy with or without IS in multiple animal models of transplantation. Methods and Results. PubMed, Medline, Embase, and the Cochrane Library were searched for reviews published up to April 2015. Six systematic reviews and a total of 61 articles were finally included. Data were grouped by organ transplantation models and applied to meta-analysis. Our meta-analysis shows that Tol-DC therapy successfully prolonged allograft survival to varying extents in all except the islet transplantation models and with IS drugs further prolonged the survival of heart, skin, and islet allografts in mice, but not of heart allografts in rats. Compared with IS drugs alone, Tol-DC therapy with IS extended islet allograft survival in rats but failed to influence the survival of skin, small intestine, and heart allografts in rats or of heart and skin allografts in mice. Conclusion. Tol-DC therapy significantly prolonged multiple allograft survival and further prolonged survival with IS. However, standardized protocols for modification of Tol-DC should be established before its application in clinic.http://dx.doi.org/10.1155/2016/5730674 |
| spellingShingle | Yanni Zhou Juan Shan Yingjia Guo Shengfu Li Dan Long Youping Li Li Feng Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews Journal of Immunology Research |
| title | Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews |
| title_full | Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews |
| title_fullStr | Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews |
| title_full_unstemmed | Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews |
| title_short | Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews |
| title_sort | effects of adoptive transfer of tolerogenic dendritic cells on allograft survival in organ transplantation models an overview of systematic reviews |
| url | http://dx.doi.org/10.1155/2016/5730674 |
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