Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits
Objective. The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model. Study Design. Thirty skeletally mature male New Zealand...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/649026 |
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| author | Ufuk Tatli Yakup Üstün Mehmet Kürkçü Mehmet Emre Benlidayı |
| author_facet | Ufuk Tatli Yakup Üstün Mehmet Kürkçü Mehmet Emre Benlidayı |
| author_sort | Ufuk Tatli |
| collection | DOAJ |
| description | Objective. The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model.
Study Design. Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump. The control group was administered only saline infusion for 15 minutes. All rabbits were sacrificed on the 21st postoperative day. Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles. The data were analyzed statistically.
Results. Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle. This result was supported by the histomorphometric findings.
Conclusion. The present study has revealed that a temporary delay in the physiological bone remodeling using single dose of ZA increases bone mineral content and makes the microarchitecture of the mandibular condyle more compact. These effects may be regarded as base data and considered in numerous clinical situations including TMJ. |
| format | Article |
| id | doaj-art-90672cbf14884a0097d89a87813b0c9c |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-90672cbf14884a0097d89a87813b0c9c2025-02-03T01:10:59ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/649026649026Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in RabbitsUfuk Tatli0Yakup Üstün1Mehmet Kürkçü2Mehmet Emre Benlidayı3Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Saricam-Balcali, 01330 Adana, TurkeyPrivate Practice in Oral and Maxillofacial Surgery, 01120 Adana, TurkeyDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Saricam-Balcali, 01330 Adana, TurkeyDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Saricam-Balcali, 01330 Adana, TurkeyObjective. The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model. Study Design. Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump. The control group was administered only saline infusion for 15 minutes. All rabbits were sacrificed on the 21st postoperative day. Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles. The data were analyzed statistically. Results. Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle. This result was supported by the histomorphometric findings. Conclusion. The present study has revealed that a temporary delay in the physiological bone remodeling using single dose of ZA increases bone mineral content and makes the microarchitecture of the mandibular condyle more compact. These effects may be regarded as base data and considered in numerous clinical situations including TMJ.http://dx.doi.org/10.1155/2014/649026 |
| spellingShingle | Ufuk Tatli Yakup Üstün Mehmet Kürkçü Mehmet Emre Benlidayı Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits The Scientific World Journal |
| title | Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits |
| title_full | Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits |
| title_fullStr | Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits |
| title_full_unstemmed | Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits |
| title_short | Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits |
| title_sort | effects of zoledronic acid on physiologic bone remodeling of condylar part of tmj a radiologic and histomorphometric examination in rabbits |
| url | http://dx.doi.org/10.1155/2014/649026 |
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