Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes
Objective. Determine the impact of Orlistat-induced weight loss on metabolic profile and cardiovascular function in severely obese patients with type 2 diabetes. Methods. Twenty-nine patients were randomized either to a nonplacebo control group or to a treatment group with Orlistat thrice a day. Met...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/394658 |
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| author | Julie Martin Carmen Paquette Simon Marceau Frédéric-Simon Hould Stéfane Lebel Serge Simard Jean-Gaston Dumesnil Paul Poirier |
| author_facet | Julie Martin Carmen Paquette Simon Marceau Frédéric-Simon Hould Stéfane Lebel Serge Simard Jean-Gaston Dumesnil Paul Poirier |
| author_sort | Julie Martin |
| collection | DOAJ |
| description | Objective. Determine the impact of Orlistat-induced weight loss on metabolic profile and cardiovascular function in severely obese patients with type 2 diabetes. Methods. Twenty-nine patients were randomized either to a nonplacebo control group or to a treatment group with Orlistat thrice a day. Metabolic profile, anthropometric parameters, heart rate variability indices, and echocardiographic variables were measured before and after a 12-week treatment period. Results. Treatment with Orlistat induced a modest but significant weight loss compared to controls (3.7 ± 3.0 versus 0.5 ± 2.2 kg, resp.; P=.003). There was significant decrease in fasting glycemia (7.9 ± 3.0 versus 6.7 ± 2.2 mmol/L; P=.03) and significant improvements in left ventricular diastolic function (P=.03) and in the sympathovagal balance (LF/HF ratio) (P=.04) in the Orlistat group. Conclusion. These results suggest that a modest weight loss improves fasting glycemia, left ventricular diastolic function, and sympathovagal balance in severely obese patients with type 2 diabetes. |
| format | Article |
| id | doaj-art-90488b6dbd6d42eaa9fb12241d4e950b |
| institution | DOAJ |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-90488b6dbd6d42eaa9fb12241d4e950b2025-08-20T03:20:30ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/394658394658Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with DiabetesJulie Martin0Carmen Paquette1Simon Marceau2Frédéric-Simon Hould3Stéfane Lebel4Serge Simard5Jean-Gaston Dumesnil6Paul Poirier7Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), 2725 Chemin Ste-Foy, QC, G1V 4G5, CanadaObjective. Determine the impact of Orlistat-induced weight loss on metabolic profile and cardiovascular function in severely obese patients with type 2 diabetes. Methods. Twenty-nine patients were randomized either to a nonplacebo control group or to a treatment group with Orlistat thrice a day. Metabolic profile, anthropometric parameters, heart rate variability indices, and echocardiographic variables were measured before and after a 12-week treatment period. Results. Treatment with Orlistat induced a modest but significant weight loss compared to controls (3.7 ± 3.0 versus 0.5 ± 2.2 kg, resp.; P=.003). There was significant decrease in fasting glycemia (7.9 ± 3.0 versus 6.7 ± 2.2 mmol/L; P=.03) and significant improvements in left ventricular diastolic function (P=.03) and in the sympathovagal balance (LF/HF ratio) (P=.04) in the Orlistat group. Conclusion. These results suggest that a modest weight loss improves fasting glycemia, left ventricular diastolic function, and sympathovagal balance in severely obese patients with type 2 diabetes.http://dx.doi.org/10.1155/2011/394658 |
| spellingShingle | Julie Martin Carmen Paquette Simon Marceau Frédéric-Simon Hould Stéfane Lebel Serge Simard Jean-Gaston Dumesnil Paul Poirier Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes Journal of Obesity |
| title | Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes |
| title_full | Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes |
| title_fullStr | Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes |
| title_full_unstemmed | Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes |
| title_short | Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes |
| title_sort | impact of orlistat induced weight loss on diastolic function and heart rate variability in severely obese subjects with diabetes |
| url | http://dx.doi.org/10.1155/2011/394658 |
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