Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis
Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world’s population is latently infected with TB and 5–15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may cause 10–20 new infections. Host i...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/5212910 |
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| author | Kai Ling Chin Fadhilah Zulkipli Anis Maria E. Sarmiento Mohd Nor Norazmi Armando Acosta |
| author_facet | Kai Ling Chin Fadhilah Zulkipli Anis Maria E. Sarmiento Mohd Nor Norazmi Armando Acosta |
| author_sort | Kai Ling Chin |
| collection | DOAJ |
| description | Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world’s population is latently infected with TB and 5–15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may cause 10–20 new infections. Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs). The latter that consists of IFN-γ has been associated with the promotion of Th1 immune response which is associated with protection against TB. Although this aspect remains controversial at present due to the lack of established correlates of protection, currently, there are different prophylactic, diagnostic, and immunotherapeutic approaches in which IFNs play an important role. This review summarizes the main aspects related with the biology of IFNs, mainly associated with TB, as well as presents the main applications of these cytokines related to prophylaxis, diagnosis, and immunotherapy of TB. |
| format | Article |
| id | doaj-art-9042eec6b2eb4b75a184d2717ab654e0 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9042eec6b2eb4b75a184d2717ab654e02025-02-03T06:12:46ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/52129105212910Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for TuberculosisKai Ling Chin0Fadhilah Zulkipli Anis1Maria E. Sarmiento2Mohd Nor Norazmi3Armando Acosta4School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaTuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world’s population is latently infected with TB and 5–15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may cause 10–20 new infections. Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs). The latter that consists of IFN-γ has been associated with the promotion of Th1 immune response which is associated with protection against TB. Although this aspect remains controversial at present due to the lack of established correlates of protection, currently, there are different prophylactic, diagnostic, and immunotherapeutic approaches in which IFNs play an important role. This review summarizes the main aspects related with the biology of IFNs, mainly associated with TB, as well as presents the main applications of these cytokines related to prophylaxis, diagnosis, and immunotherapy of TB.http://dx.doi.org/10.1155/2017/5212910 |
| spellingShingle | Kai Ling Chin Fadhilah Zulkipli Anis Maria E. Sarmiento Mohd Nor Norazmi Armando Acosta Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis Journal of Immunology Research |
| title | Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis |
| title_full | Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis |
| title_fullStr | Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis |
| title_full_unstemmed | Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis |
| title_short | Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis |
| title_sort | role of interferons in the development of diagnostics vaccines and therapy for tuberculosis |
| url | http://dx.doi.org/10.1155/2017/5212910 |
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