Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization?
The locus coeruleus-norepinephrine (LC-NE) system is thought to act at synaptic, cellular, microcircuit, and network levels to facilitate cognitive functions through at least two different processes, not mutually exclusive. Accordingly, as a reset signal, the LC-NE system could trigger brain network...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/4328015 |
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| author | Carole Guedj David Meunier Martine Meunier Fadila Hadj-Bouziane |
| author_facet | Carole Guedj David Meunier Martine Meunier Fadila Hadj-Bouziane |
| author_sort | Carole Guedj |
| collection | DOAJ |
| description | The locus coeruleus-norepinephrine (LC-NE) system is thought to act at synaptic, cellular, microcircuit, and network levels to facilitate cognitive functions through at least two different processes, not mutually exclusive. Accordingly, as a reset signal, the LC-NE system could trigger brain network reorganizations in response to salient information in the environment and/or adjust the neural gain within its target regions to optimize behavioral responses. Here, we provide evidence of the co-occurrence of these two mechanisms at the whole-brain level, in resting-state conditions following a pharmacological stimulation of the LC-NE system. We propose that these two mechanisms are interdependent such that the LC-NE-dependent adjustment of the neural gain inferred from the clustering coefficient could drive functional brain network reorganizations through coherence in the gamma rhythm. Via the temporal dynamic of gamma-range band-limited power, the release of NE could adjust the neural gain, promoting interactions only within the neuronal populations whose amplitude envelopes are correlated, thus making it possible to reorganize neuronal ensembles, functional networks, and ultimately, behavioral responses. Thus, our proposal offers a unified framework integrating the putative influence of the LC-NE system on both local- and long-range adjustments of brain dynamics underlying behavioral flexibility. |
| format | Article |
| id | doaj-art-903fe533ab8a45a0a40d7fc269779fc2 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-903fe533ab8a45a0a40d7fc269779fc22025-02-03T01:11:20ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/43280154328015Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization?Carole Guedj0David Meunier1Martine Meunier2Fadila Hadj-Bouziane3INSERM, U1028, CNRS UMR5292, Lyon Neuroscience Research Center, ImpAct Team, 69000 Lyon, FranceINSERM, U1028, CNRS UMR5292, Lyon Neuroscience Research Center, ImpAct Team, 69000 Lyon, FranceINSERM, U1028, CNRS UMR5292, Lyon Neuroscience Research Center, ImpAct Team, 69000 Lyon, FranceINSERM, U1028, CNRS UMR5292, Lyon Neuroscience Research Center, ImpAct Team, 69000 Lyon, FranceThe locus coeruleus-norepinephrine (LC-NE) system is thought to act at synaptic, cellular, microcircuit, and network levels to facilitate cognitive functions through at least two different processes, not mutually exclusive. Accordingly, as a reset signal, the LC-NE system could trigger brain network reorganizations in response to salient information in the environment and/or adjust the neural gain within its target regions to optimize behavioral responses. Here, we provide evidence of the co-occurrence of these two mechanisms at the whole-brain level, in resting-state conditions following a pharmacological stimulation of the LC-NE system. We propose that these two mechanisms are interdependent such that the LC-NE-dependent adjustment of the neural gain inferred from the clustering coefficient could drive functional brain network reorganizations through coherence in the gamma rhythm. Via the temporal dynamic of gamma-range band-limited power, the release of NE could adjust the neural gain, promoting interactions only within the neuronal populations whose amplitude envelopes are correlated, thus making it possible to reorganize neuronal ensembles, functional networks, and ultimately, behavioral responses. Thus, our proposal offers a unified framework integrating the putative influence of the LC-NE system on both local- and long-range adjustments of brain dynamics underlying behavioral flexibility.http://dx.doi.org/10.1155/2017/4328015 |
| spellingShingle | Carole Guedj David Meunier Martine Meunier Fadila Hadj-Bouziane Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization? Neural Plasticity |
| title | Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization? |
| title_full | Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization? |
| title_fullStr | Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization? |
| title_full_unstemmed | Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization? |
| title_short | Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization? |
| title_sort | could lc ne dependent adjustment of neural gain drive functional brain network reorganization |
| url | http://dx.doi.org/10.1155/2017/4328015 |
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