Solvent Free Synthesis of Chalcones and their Antibacterial Activities
The solvent free synthesis of six chalcones was carried out by grinding the piperanal and the acetophenone (unsubstituted, 4-methyl, 4-methoxy, 4-bromo, 4-nitro, 3-chloro) in the presence of solid sodium hydroxide with a mortar and pestle. In general, the chalcones were obtained in high yield and hi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2005/294094 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563103572688896 |
|---|---|
| author | K. Rajendra K. Saini S. Amit Choudhary Yogesh. C. Joshi P. Joshi |
| author_facet | K. Rajendra K. Saini S. Amit Choudhary Yogesh. C. Joshi P. Joshi |
| author_sort | K. Rajendra K. Saini |
| collection | DOAJ |
| description | The solvent free synthesis of six chalcones was carried out by grinding the piperanal and the acetophenone (unsubstituted, 4-methyl, 4-methoxy, 4-bromo, 4-nitro, 3-chloro) in the presence of solid sodium hydroxide with a mortar and pestle. In general, the chalcones were obtained in high yield and high purity. Minor quantities of Ketol and Michael addition product were easily removed by recrystallization. The result indicates a correlation between the success of the solvent-free synthesis and melting point of the chalcone. Chalcone with relatively high melting points (higher than 80°C) were obtained in high yields. The two chalcones that could not be produced in good yields were having relatively low melting points. They have been screened for their antibacterial activity against Gram positive and Gram negative bacteria. |
| format | Article |
| id | doaj-art-9029704295f1475494bf5590020b95a6 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-9029704295f1475494bf5590020b95a62025-02-03T01:20:59ZengWileyE-Journal of Chemistry0973-49452090-98102005-01-012422422710.1155/2005/294094Solvent Free Synthesis of Chalcones and their Antibacterial ActivitiesK. Rajendra K. Saini0S. Amit Choudhary1Yogesh. C. Joshi2P. Joshi3Department of Chemistry, University of Rajasthan, Jaipur–302004, IndiaDepartment of Chemistry, University of Rajasthan, Jaipur–302004, IndiaDepartment of Chemistry, University of Rajasthan, Jaipur–302004, IndiaS.S. Jain Subodh P.G. College, Jaipur-302004, Rajasthan, IndiaThe solvent free synthesis of six chalcones was carried out by grinding the piperanal and the acetophenone (unsubstituted, 4-methyl, 4-methoxy, 4-bromo, 4-nitro, 3-chloro) in the presence of solid sodium hydroxide with a mortar and pestle. In general, the chalcones were obtained in high yield and high purity. Minor quantities of Ketol and Michael addition product were easily removed by recrystallization. The result indicates a correlation between the success of the solvent-free synthesis and melting point of the chalcone. Chalcone with relatively high melting points (higher than 80°C) were obtained in high yields. The two chalcones that could not be produced in good yields were having relatively low melting points. They have been screened for their antibacterial activity against Gram positive and Gram negative bacteria.http://dx.doi.org/10.1155/2005/294094 |
| spellingShingle | K. Rajendra K. Saini S. Amit Choudhary Yogesh. C. Joshi P. Joshi Solvent Free Synthesis of Chalcones and their Antibacterial Activities E-Journal of Chemistry |
| title | Solvent Free Synthesis of Chalcones and their Antibacterial Activities |
| title_full | Solvent Free Synthesis of Chalcones and their Antibacterial Activities |
| title_fullStr | Solvent Free Synthesis of Chalcones and their Antibacterial Activities |
| title_full_unstemmed | Solvent Free Synthesis of Chalcones and their Antibacterial Activities |
| title_short | Solvent Free Synthesis of Chalcones and their Antibacterial Activities |
| title_sort | solvent free synthesis of chalcones and their antibacterial activities |
| url | http://dx.doi.org/10.1155/2005/294094 |
| work_keys_str_mv | AT krajendraksaini solventfreesynthesisofchalconesandtheirantibacterialactivities AT samitchoudhary solventfreesynthesisofchalconesandtheirantibacterialactivities AT yogeshcjoshi solventfreesynthesisofchalconesandtheirantibacterialactivities AT pjoshi solventfreesynthesisofchalconesandtheirantibacterialactivities |