Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion
Introduction. Diquat is an herbicide that can lead to rapid multiorgan system failure upon toxic ingestion. Although Diquat shares a similar chemical structure with paraquat, diquat is still readily available to the general population, and in contrast to paraquat, it is not regulated. We present a c...
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/4723092 |
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| author | Daniel Guck Reynaldo Hernandez Steven Moore Andry Van de Louw Philippe Haouzi |
| author_facet | Daniel Guck Reynaldo Hernandez Steven Moore Andry Van de Louw Philippe Haouzi |
| author_sort | Daniel Guck |
| collection | DOAJ |
| description | Introduction. Diquat is an herbicide that can lead to rapid multiorgan system failure upon toxic ingestion. Although Diquat shares a similar chemical structure with paraquat, diquat is still readily available to the general population, and in contrast to paraquat, it is not regulated. We present a case of an intentional diquat poisoning which emphasizes the necessity of the early recognition due to atypical symptoms within the first 24 hours and certainly enhanced regulatory restrictions on this very toxic compound. Case. A 60-year-old male with a history of severe depression presented to the emergency department after intentional ingestion of a commercial herbicide containing diquat dibromide 2.30%. The earliest manifestations of this acute diquat intoxication comprised a glomerulonephritis and proximal tubular dysfunction. Progressive multiorgan system failure then developed with a significant delay (24–38 hours) including acute renal, liver failure, and then respiratory failure with refractory hypoxemia. Despite maximal supportive care, the end organ failure was lethal. Discussion. Diquat intoxication should be suspected in patient presenting an acute glomerulonephritis with coma. Diquat should undergo the same regulatory restrictions as paraquat-containing compounds. |
| format | Article |
| id | doaj-art-9028d92890a14ffbbabb01278d738beb |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-9028d92890a14ffbbabb01278d738beb2025-02-03T07:24:22ZengWileyCase Reports in Nephrology2090-66412090-665X2021-01-01202110.1155/2021/47230924723092Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat IngestionDaniel Guck0Reynaldo Hernandez1Steven Moore2Andry Van de Louw3Philippe Haouzi4Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USADepartment of Emergency Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USADepartment of Emergency Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USAIntroduction. Diquat is an herbicide that can lead to rapid multiorgan system failure upon toxic ingestion. Although Diquat shares a similar chemical structure with paraquat, diquat is still readily available to the general population, and in contrast to paraquat, it is not regulated. We present a case of an intentional diquat poisoning which emphasizes the necessity of the early recognition due to atypical symptoms within the first 24 hours and certainly enhanced regulatory restrictions on this very toxic compound. Case. A 60-year-old male with a history of severe depression presented to the emergency department after intentional ingestion of a commercial herbicide containing diquat dibromide 2.30%. The earliest manifestations of this acute diquat intoxication comprised a glomerulonephritis and proximal tubular dysfunction. Progressive multiorgan system failure then developed with a significant delay (24–38 hours) including acute renal, liver failure, and then respiratory failure with refractory hypoxemia. Despite maximal supportive care, the end organ failure was lethal. Discussion. Diquat intoxication should be suspected in patient presenting an acute glomerulonephritis with coma. Diquat should undergo the same regulatory restrictions as paraquat-containing compounds.http://dx.doi.org/10.1155/2021/4723092 |
| spellingShingle | Daniel Guck Reynaldo Hernandez Steven Moore Andry Van de Louw Philippe Haouzi Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion Case Reports in Nephrology |
| title | Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion |
| title_full | Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion |
| title_fullStr | Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion |
| title_full_unstemmed | Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion |
| title_short | Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion |
| title_sort | rapid glomerulotubular nephritis as an initial presentation of a lethal diquat ingestion |
| url | http://dx.doi.org/10.1155/2021/4723092 |
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