Multifaceted roles of ninjurin1 in immunity, cell death, and disease
Ninjurin1 (NINJ1) is initially identified as a nerve injury-induced adhesion molecule that facilitates axon growth. It is initially characterized to promote nerve regeneration and mediate the transendothelial transport of monocytes/macrophages associated with neuroinflammation. Recent evidence indic...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519519/full |
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| author | Lili Zhu Yunfei Xu Yunfei Xu |
| author_facet | Lili Zhu Yunfei Xu Yunfei Xu |
| author_sort | Lili Zhu |
| collection | DOAJ |
| description | Ninjurin1 (NINJ1) is initially identified as a nerve injury-induced adhesion molecule that facilitates axon growth. It is initially characterized to promote nerve regeneration and mediate the transendothelial transport of monocytes/macrophages associated with neuroinflammation. Recent evidence indicates that NINJ1 mediates plasma membrane rupture (PMR) in lytic cell death. The absence or inhibition of NINJ1 can delay PMR, thereby mitigating the spread of inflammation resulting from cell lysis and preventing the progression of various cell death-related pathologies, suggesting a conserved regulatory mechanism across these processes. Further research elucidated the structural basis and mechanism of NINJ1-mediated PMR. Although the role of NINJ1 in PMR is established, the identity of its activating factors and its implications in diseases remain to be fully explored. This review synthesizes current knowledge regarding the structural basis and mechanism of NINJ1-mediated PMR and discusses its significance and therapeutic targeting potential in inflammatory diseases, neurological disorders, cancer, and vascular injuries. |
| format | Article |
| id | doaj-art-901f90a0d34140bebb938174743423cc |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-901f90a0d34140bebb938174743423cc2025-01-31T06:39:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15195191519519Multifaceted roles of ninjurin1 in immunity, cell death, and diseaseLili Zhu0Yunfei Xu1Yunfei Xu2Department of Pathology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, ChinaPostdoctoral Research Station of Biology, School of Basic Medical Science, Central South University, Changsha, Hunan, ChinaNinjurin1 (NINJ1) is initially identified as a nerve injury-induced adhesion molecule that facilitates axon growth. It is initially characterized to promote nerve regeneration and mediate the transendothelial transport of monocytes/macrophages associated with neuroinflammation. Recent evidence indicates that NINJ1 mediates plasma membrane rupture (PMR) in lytic cell death. The absence or inhibition of NINJ1 can delay PMR, thereby mitigating the spread of inflammation resulting from cell lysis and preventing the progression of various cell death-related pathologies, suggesting a conserved regulatory mechanism across these processes. Further research elucidated the structural basis and mechanism of NINJ1-mediated PMR. Although the role of NINJ1 in PMR is established, the identity of its activating factors and its implications in diseases remain to be fully explored. This review synthesizes current knowledge regarding the structural basis and mechanism of NINJ1-mediated PMR and discusses its significance and therapeutic targeting potential in inflammatory diseases, neurological disorders, cancer, and vascular injuries.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519519/fullcancerinflammationlytic cell deathneurological diseasesninjurin1plasma membrane rupture |
| spellingShingle | Lili Zhu Yunfei Xu Yunfei Xu Multifaceted roles of ninjurin1 in immunity, cell death, and disease Frontiers in Immunology cancer inflammation lytic cell death neurological diseases ninjurin1 plasma membrane rupture |
| title | Multifaceted roles of ninjurin1 in immunity, cell death, and disease |
| title_full | Multifaceted roles of ninjurin1 in immunity, cell death, and disease |
| title_fullStr | Multifaceted roles of ninjurin1 in immunity, cell death, and disease |
| title_full_unstemmed | Multifaceted roles of ninjurin1 in immunity, cell death, and disease |
| title_short | Multifaceted roles of ninjurin1 in immunity, cell death, and disease |
| title_sort | multifaceted roles of ninjurin1 in immunity cell death and disease |
| topic | cancer inflammation lytic cell death neurological diseases ninjurin1 plasma membrane rupture |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519519/full |
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