A bioabsorbable mechanoelectric fiber as electrical stimulation suture
Abstract In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation is a non-pharmacological therapy that promotes wound healing. In this context, we designed a passive and biodegradable mechanoelectric s...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-52354-x |
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| author | Zhouquan Sun Yuefan Jin Jiabei Luo Linpeng Li Yue Ding Yu Luo Yan Qi Yaogang Li Qinghong Zhang Kerui Li Haibo Shi Shankai Yin Hongzhi Wang Hui Wang Chengyi Hou |
| author_facet | Zhouquan Sun Yuefan Jin Jiabei Luo Linpeng Li Yue Ding Yu Luo Yan Qi Yaogang Li Qinghong Zhang Kerui Li Haibo Shi Shankai Yin Hongzhi Wang Hui Wang Chengyi Hou |
| author_sort | Zhouquan Sun |
| collection | DOAJ |
| description | Abstract In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation is a non-pharmacological therapy that promotes wound healing. In this context, we designed a passive and biodegradable mechanoelectric suture. The suture consists of multi-layer coaxial structure composed of (poly(lactic-co-glycolic acid), polycaprolactone) and magnesium to allow safe degradation. In addition to the excellent mechanical properties, the mechanoelectrical nature of the suture grants the generation of electric fields in response to movement and stretching. This is shown to speed up wound healing by 50% and reduce the risk of infection. This work presents an evolution of the conventional wound closure procedures, using a safe and degradable device ready to be translated into clinical practice. |
| format | Article |
| id | doaj-art-9003707ee4ef4d41a4f7795da4c7cc30 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-9003707ee4ef4d41a4f7795da4c7cc302025-01-26T12:40:11ZengNature PortfolioNature Communications2041-17232024-10-0115111210.1038/s41467-024-52354-xA bioabsorbable mechanoelectric fiber as electrical stimulation sutureZhouquan Sun0Yuefan Jin1Jiabei Luo2Linpeng Li3Yue Ding4Yu Luo5Yan Qi6Yaogang Li7Qinghong Zhang8Kerui Li9Haibo Shi10Shankai Yin11Hongzhi Wang12Hui Wang13Chengyi Hou14State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniversityShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniversityShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Tongji Hospital, Tongji University Medical SchoolShanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Institute for Frontier Medical Technology, School of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceYangzhi Rehabilitation Hospital Affiliated to Tongji University, Tongji University School of MedicineState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniversityState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniversityState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniversityShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniversityShanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua UniversityAbstract In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation is a non-pharmacological therapy that promotes wound healing. In this context, we designed a passive and biodegradable mechanoelectric suture. The suture consists of multi-layer coaxial structure composed of (poly(lactic-co-glycolic acid), polycaprolactone) and magnesium to allow safe degradation. In addition to the excellent mechanical properties, the mechanoelectrical nature of the suture grants the generation of electric fields in response to movement and stretching. This is shown to speed up wound healing by 50% and reduce the risk of infection. This work presents an evolution of the conventional wound closure procedures, using a safe and degradable device ready to be translated into clinical practice.https://doi.org/10.1038/s41467-024-52354-x |
| spellingShingle | Zhouquan Sun Yuefan Jin Jiabei Luo Linpeng Li Yue Ding Yu Luo Yan Qi Yaogang Li Qinghong Zhang Kerui Li Haibo Shi Shankai Yin Hongzhi Wang Hui Wang Chengyi Hou A bioabsorbable mechanoelectric fiber as electrical stimulation suture Nature Communications |
| title | A bioabsorbable mechanoelectric fiber as electrical stimulation suture |
| title_full | A bioabsorbable mechanoelectric fiber as electrical stimulation suture |
| title_fullStr | A bioabsorbable mechanoelectric fiber as electrical stimulation suture |
| title_full_unstemmed | A bioabsorbable mechanoelectric fiber as electrical stimulation suture |
| title_short | A bioabsorbable mechanoelectric fiber as electrical stimulation suture |
| title_sort | bioabsorbable mechanoelectric fiber as electrical stimulation suture |
| url | https://doi.org/10.1038/s41467-024-52354-x |
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