Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults
Abstract Introduction As no standard case definitions for respiratory syncytial virus—associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data in hospital and community cohorts of adults with RSV...
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Adis, Springer Healthcare
2024-11-01
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| Series: | Infectious Diseases and Therapy |
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| Online Access: | https://doi.org/10.1007/s40121-024-01072-4 |
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| author | Catherine A. Panozzo Edward E. Walsh Zhen Yang Eleanor Wilson Jaya Goswami Sonia K. Stoszek Adrianna Loback Tony Ng Beverly M. Francis Alana K. Simorellis Wenmei Huang Linwei Li Rebecca Vislay-Wade Zhe Zheng Evan J. Anderson Allison August Grace Chen Ann R. Falsey |
| author_facet | Catherine A. Panozzo Edward E. Walsh Zhen Yang Eleanor Wilson Jaya Goswami Sonia K. Stoszek Adrianna Loback Tony Ng Beverly M. Francis Alana K. Simorellis Wenmei Huang Linwei Li Rebecca Vislay-Wade Zhe Zheng Evan J. Anderson Allison August Grace Chen Ann R. Falsey |
| author_sort | Catherine A. Panozzo |
| collection | DOAJ |
| description | Abstract Introduction As no standard case definitions for respiratory syncytial virus—associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data in hospital and community cohorts of adults with RSV–associated symptoms. Methods The frequency, sensitivity, and specificity of acute respiratory disease symptoms among hospitalized and community cohorts of adults with RSV were analyzed. RSV-LRTD signs/symptoms assessed included shortness of breath (dyspnea), cough and/or fever, wheezing/rales/rhonchi (abnormal lung sounds by auscultation), sputum production, tachypnea, hypoxemia, and pleuritic chest pain. Results Dyspnea and tachypnea provided the best differentiation between hospitalized and community RSV-positive cases. The severe RSV-LRTD case definition yielding one of the highest and best-balanced sensitivity and specificity was dyspnea paired with either abnormal lung sounds by auscultation, hypoxemia, tachypnea, cough and/or fever, sputum, or chest pain. Conclusions Dyspnea alone, and in combination with certain other lower respiratory tract disease signs/symptoms, was a leading symptomatic indicator for severe RSV outcomes. These results contribute to the harmonization of case definitions for RSV disease. |
| format | Article |
| id | doaj-art-900087d595774a10b3c20827c8e17df6 |
| institution | Kabale University |
| issn | 2193-8229 2193-6382 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj-art-900087d595774a10b3c20827c8e17df62025-02-02T12:35:19ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822024-11-0114127528110.1007/s40121-024-01072-4Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in AdultsCatherine A. Panozzo0Edward E. Walsh1Zhen Yang2Eleanor Wilson3Jaya Goswami4Sonia K. Stoszek5Adrianna Loback6Tony Ng7Beverly M. Francis8Alana K. Simorellis9Wenmei Huang10Linwei Li11Rebecca Vislay-Wade12Zhe Zheng13Evan J. Anderson14Allison August15Grace Chen16Ann R. Falsey17Infectious Disease Clinical Development, Moderna, Inc.Department of Medicine, University of RochesterData Science and Artificial Intelligence, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Data Science and Artificial Intelligence, Moderna, Inc.Data Science and Artificial Intelligence, Moderna, Inc.Medical Affairs, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Clinical Development Operations, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Data Science and Artificial Intelligence, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Infectious Disease Clinical Development, Moderna, Inc.Department of Medicine, University of RochesterAbstract Introduction As no standard case definitions for respiratory syncytial virus—associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data in hospital and community cohorts of adults with RSV–associated symptoms. Methods The frequency, sensitivity, and specificity of acute respiratory disease symptoms among hospitalized and community cohorts of adults with RSV were analyzed. RSV-LRTD signs/symptoms assessed included shortness of breath (dyspnea), cough and/or fever, wheezing/rales/rhonchi (abnormal lung sounds by auscultation), sputum production, tachypnea, hypoxemia, and pleuritic chest pain. Results Dyspnea and tachypnea provided the best differentiation between hospitalized and community RSV-positive cases. The severe RSV-LRTD case definition yielding one of the highest and best-balanced sensitivity and specificity was dyspnea paired with either abnormal lung sounds by auscultation, hypoxemia, tachypnea, cough and/or fever, sputum, or chest pain. Conclusions Dyspnea alone, and in combination with certain other lower respiratory tract disease signs/symptoms, was a leading symptomatic indicator for severe RSV outcomes. These results contribute to the harmonization of case definitions for RSV disease.https://doi.org/10.1007/s40121-024-01072-4Case definitionsLower respiratory tract diseaseOlder adultsRespiratory syncytial virusSevere respiratory syncytial virus |
| spellingShingle | Catherine A. Panozzo Edward E. Walsh Zhen Yang Eleanor Wilson Jaya Goswami Sonia K. Stoszek Adrianna Loback Tony Ng Beverly M. Francis Alana K. Simorellis Wenmei Huang Linwei Li Rebecca Vislay-Wade Zhe Zheng Evan J. Anderson Allison August Grace Chen Ann R. Falsey Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults Infectious Diseases and Therapy Case definitions Lower respiratory tract disease Older adults Respiratory syncytial virus Severe respiratory syncytial virus |
| title | Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults |
| title_full | Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults |
| title_fullStr | Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults |
| title_full_unstemmed | Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults |
| title_short | Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults |
| title_sort | leveraging real world evidence to define severe rsv lower respiratory tract disease in adults |
| topic | Case definitions Lower respiratory tract disease Older adults Respiratory syncytial virus Severe respiratory syncytial virus |
| url | https://doi.org/10.1007/s40121-024-01072-4 |
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