Minimal state models for ionic channels involved in glucagon secretion
Pancreatic alpha cells synthesize and release glucagon. This hormone along with insulin, preserves blood glucose levels within a physiological range. During low glucose levels, alpha cells exhibit electrical activity related to glucagon secretion.In this paper, we introduce minimal state models for...
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AIMS Press
2010-09-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.793 |
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| author | Virginia González-Vélez Amparo Gil Iván Quesada |
| author_facet | Virginia González-Vélez Amparo Gil Iván Quesada |
| author_sort | Virginia González-Vélez |
| collection | DOAJ |
| description | Pancreatic alpha cells synthesize and release glucagon. This hormone along with insulin, preserves blood glucose levels within a physiological range. During low glucose levels, alpha cells exhibit electrical activity related to glucagon secretion.In this paper, we introduce minimal state models for those ionic channels involved in this electrical activity in mice alpha cells. For estimation of model parameters, we use Monte Carlo algorithms to fit steady-state channel currents. Then, we simulate dynamic ionic currents following experimental protocols.Our aims are 1) To understand the individual ionic channel functioning and modulation that could affect glucagon secretion, and 2) To simulate ionic currents actually measured in voltage-clamp alpha-cell experiments in mice.Our estimations indicate that alpha cells are highly permeable to sodium and potassium which mainly manage action potentials. We have also found that our estimated N-type calcium channel population and density in alpha cells is in good agreement to those reported for L-type calcium channelsin beta cells. This finding is strongly relevant since both, L-type and N-type calcium channels, play a main role in insulin and glucagon secretion, respectively. |
| format | Article |
| id | doaj-art-8ffae3b20f19462e8f29d599d5472c11 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2010-09-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-8ffae3b20f19462e8f29d599d5472c112025-01-24T02:00:58ZengAIMS PressMathematical Biosciences and Engineering1551-00182010-09-017479380710.3934/mbe.2010.7.793Minimal state models for ionic channels involved in glucagon secretionVirginia González-Vélez0Amparo Gil1Iván Quesada2Dept. Ciencias Básicas, Universidad Autónoma Metropolitana Azcapotzalco, México D.F., 02200Dept. Ciencias Básicas, Universidad Autónoma Metropolitana Azcapotzalco, México D.F., 02200Dept. Ciencias Básicas, Universidad Autónoma Metropolitana Azcapotzalco, México D.F., 02200Pancreatic alpha cells synthesize and release glucagon. This hormone along with insulin, preserves blood glucose levels within a physiological range. During low glucose levels, alpha cells exhibit electrical activity related to glucagon secretion.In this paper, we introduce minimal state models for those ionic channels involved in this electrical activity in mice alpha cells. For estimation of model parameters, we use Monte Carlo algorithms to fit steady-state channel currents. Then, we simulate dynamic ionic currents following experimental protocols.Our aims are 1) To understand the individual ionic channel functioning and modulation that could affect glucagon secretion, and 2) To simulate ionic currents actually measured in voltage-clamp alpha-cell experiments in mice.Our estimations indicate that alpha cells are highly permeable to sodium and potassium which mainly manage action potentials. We have also found that our estimated N-type calcium channel population and density in alpha cells is in good agreement to those reported for L-type calcium channelsin beta cells. This finding is strongly relevant since both, L-type and N-type calcium channels, play a main role in insulin and glucagon secretion, respectively.https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.793markov modelsmonte carlo.ionic channelspancreatic alpha cell |
| spellingShingle | Virginia González-Vélez Amparo Gil Iván Quesada Minimal state models for ionic channels involved in glucagon secretion Mathematical Biosciences and Engineering markov models monte carlo. ionic channels pancreatic alpha cell |
| title | Minimal state models for ionic channels involved in glucagon secretion |
| title_full | Minimal state models for ionic channels involved in glucagon secretion |
| title_fullStr | Minimal state models for ionic channels involved in glucagon secretion |
| title_full_unstemmed | Minimal state models for ionic channels involved in glucagon secretion |
| title_short | Minimal state models for ionic channels involved in glucagon secretion |
| title_sort | minimal state models for ionic channels involved in glucagon secretion |
| topic | markov models monte carlo. ionic channels pancreatic alpha cell |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.793 |
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