Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369
In this study, two compounds have been isolated from the Arctic-derived fungus <i>Penicillium chrysogenum</i> INA 13460. Structural elucidation, performed using 2D NMR and HR-ESIMS data, has identified the compounds as stereoisomers of secalonic acids, dimeric tetrahydroxanthones. The ab...
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MDPI AG
2025-01-01
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| author | Yulia A. Roshka Natalia N. Markelova Sofia D. Mashkova Kseniya V. Malysheva Marina L. Georgieva Igor B. Levshin Vladimir I. Polshakov Alexander M. Arutyunian Alexey S. Vasilchenko Vera S. Sadykova |
| author_facet | Yulia A. Roshka Natalia N. Markelova Sofia D. Mashkova Kseniya V. Malysheva Marina L. Georgieva Igor B. Levshin Vladimir I. Polshakov Alexander M. Arutyunian Alexey S. Vasilchenko Vera S. Sadykova |
| author_sort | Yulia A. Roshka |
| collection | DOAJ |
| description | In this study, two compounds have been isolated from the Arctic-derived fungus <i>Penicillium chrysogenum</i> INA 13460. Structural elucidation, performed using 2D NMR and HR-ESIMS data, has identified the compounds as stereoisomers of secalonic acids, dimeric tetrahydroxanthones. The absolute configurations of these stereoisomers have been determined through conformational NMR analysis and circular dichroism spectroscopy. The antimicrobial activity of secalonic acids D and F has been evaluated against a diverse range of microorganisms, including Gram-positive multidrug-resistant <i>Staphylococcus aureus</i>, Gram-negative <i>Escherichia coli</i> ATCC 25922, <i>Pseudomonas aeruginosa</i> ATCC 27853, the phytopathogen <i>Pectobacterium carotovorum</i> VKM-B1247, and the fungi <i>Fusarium oxysporum</i> VKPM F 890, <i>Aspergillus fumigatus</i> VKM F-37, and <i>A. niger</i> ATCC 16404. Genomic and chemical analyses further support <i>P. chrysogenum</i> INA 13460 as a promising natural source for antimicrobial drug discovery and biological control applications. |
| format | Article |
| id | doaj-art-8ff05b177b9449fb80c5d317d54ab181 |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-8ff05b177b9449fb80c5d317d54ab1812025-01-24T13:18:56ZengMDPI AGAntibiotics2079-63822025-01-011418810.3390/antibiotics14010088Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369Yulia A. Roshka0Natalia N. Markelova1Sofia D. Mashkova2Kseniya V. Malysheva3Marina L. Georgieva4Igor B. Levshin5Vladimir I. Polshakov6Alexander M. Arutyunian7Alexey S. Vasilchenko8Vera S. Sadykova9Laboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, St. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaLaboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, St. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaLaboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, St. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaLaboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, St. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaLaboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, St. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaLaboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, St. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaCenter for Magnetic Tomography & Spectroscopy, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Leninskie Gory, GSP-1, 119991 Moscow, RussiaA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, GSP-1, 119991 Moscow, RussiaLaboratory of Antimicrobial Resistance, Institute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, 625003 Tyumen, RussiaLaboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, St. Bolshaya Pirogovskaya, 11, 119021 Moscow, RussiaIn this study, two compounds have been isolated from the Arctic-derived fungus <i>Penicillium chrysogenum</i> INA 13460. Structural elucidation, performed using 2D NMR and HR-ESIMS data, has identified the compounds as stereoisomers of secalonic acids, dimeric tetrahydroxanthones. The absolute configurations of these stereoisomers have been determined through conformational NMR analysis and circular dichroism spectroscopy. The antimicrobial activity of secalonic acids D and F has been evaluated against a diverse range of microorganisms, including Gram-positive multidrug-resistant <i>Staphylococcus aureus</i>, Gram-negative <i>Escherichia coli</i> ATCC 25922, <i>Pseudomonas aeruginosa</i> ATCC 27853, the phytopathogen <i>Pectobacterium carotovorum</i> VKM-B1247, and the fungi <i>Fusarium oxysporum</i> VKPM F 890, <i>Aspergillus fumigatus</i> VKM F-37, and <i>A. niger</i> ATCC 16404. Genomic and chemical analyses further support <i>P. chrysogenum</i> INA 13460 as a promising natural source for antimicrobial drug discovery and biological control applications.https://www.mdpi.com/2079-6382/14/1/88psychrotolerant fungi<i>Penicillium chrysogenum</i>antimicrobial activitysecalonic acid |
| spellingShingle | Yulia A. Roshka Natalia N. Markelova Sofia D. Mashkova Kseniya V. Malysheva Marina L. Georgieva Igor B. Levshin Vladimir I. Polshakov Alexander M. Arutyunian Alexey S. Vasilchenko Vera S. Sadykova Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369 Antibiotics psychrotolerant fungi <i>Penicillium chrysogenum</i> antimicrobial activity secalonic acid |
| title | Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369 |
| title_full | Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369 |
| title_fullStr | Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369 |
| title_full_unstemmed | Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369 |
| title_short | Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369 |
| title_sort | antimicrobial potential of secalonic acids from arctic derived i penicillium chrysogenum i ina 01369 |
| topic | psychrotolerant fungi <i>Penicillium chrysogenum</i> antimicrobial activity secalonic acid |
| url | https://www.mdpi.com/2079-6382/14/1/88 |
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