Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation
Iordanis Vagiakis,1 Eleni P Papadopoulou,1 Efstratia Amaxilati,1 Georgios N Tsiropoulos,1 Anastasios G Konstas,1,* Georgios D Panos1,2,* 1First Department of Ophthalmology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Div...
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Dove Medical Press
2025-01-01
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| author | Vagiakis I Papadopoulou EP Amaxilati E Tsiropoulos GN Konstas AG Panos GD |
| author_facet | Vagiakis I Papadopoulou EP Amaxilati E Tsiropoulos GN Konstas AG Panos GD |
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| description | Iordanis Vagiakis,1 Eleni P Papadopoulou,1 Efstratia Amaxilati,1 Georgios N Tsiropoulos,1 Anastasios G Konstas,1,* Georgios D Panos1,2,* 1First Department of Ophthalmology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Division of Ophthalmology and Visual Sciences, School of Medicine, University of Nottingham, Nottingham, UK*These authors contributed equally to this workCorrespondence: Georgios D Panos; Iordanis Vagiakis, First Department of Ophthalmology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Kiriakidi 1, Thessaloniki, 54636, Greece, Tel +30 231 330 3110, Email gdpanos@gmail.com; jvag_@outlook.comAbstract: The bimatoprost intracameral implant (Durysta®) offers a sustained-release approach to glaucoma management, providing consistent intraocular pressure (IOP) reduction over several months and reducing the need for daily topical therapies. This review evaluates its pharmacology, efficacy, and safety, using data from pivotal clinical trials and recent real-world studies. The implant achieves IOP reductions comparable to topical prostaglandin analogs, with benefits for patient adherence and fewer common side effects. However, repeat administrations are associated with adverse effects such as endothelial cell loss, highlighting the need for optimized re-dosing schedules. Future research should explore its use in advanced glaucomas, cost-effectiveness, and combination with other IOP-lowering treatments. The bimatoprost intracameral implant represents a promising innovation in glaucoma therapy with potential for improved patient outcomes.Keywords: bimatoprost intracameral implant, glaucoma, intraocular pressure reduction, sustained-release therapy, primary open-angle glaucoma, ophthalmic drug delivery, patient adherence, prostaglandin analogs, endothelial cell safety, real-world evidence, cost-effectiveness, combination therapy in glaucoma |
| format | Article |
| id | doaj-art-8fe92c96d02947908d07c0a492ea86b6 |
| institution | Kabale University |
| issn | 1177-8881 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Drug Design, Development and Therapy |
| spelling | doaj-art-8fe92c96d02947908d07c0a492ea86b62025-02-02T15:59:40ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-01-01Volume 1970371499785Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release InnovationVagiakis IPapadopoulou EPAmaxilati ETsiropoulos GNKonstas AGPanos GDIordanis Vagiakis,1 Eleni P Papadopoulou,1 Efstratia Amaxilati,1 Georgios N Tsiropoulos,1 Anastasios G Konstas,1,* Georgios D Panos1,2,* 1First Department of Ophthalmology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Division of Ophthalmology and Visual Sciences, School of Medicine, University of Nottingham, Nottingham, UK*These authors contributed equally to this workCorrespondence: Georgios D Panos; Iordanis Vagiakis, First Department of Ophthalmology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Kiriakidi 1, Thessaloniki, 54636, Greece, Tel +30 231 330 3110, Email gdpanos@gmail.com; jvag_@outlook.comAbstract: The bimatoprost intracameral implant (Durysta®) offers a sustained-release approach to glaucoma management, providing consistent intraocular pressure (IOP) reduction over several months and reducing the need for daily topical therapies. This review evaluates its pharmacology, efficacy, and safety, using data from pivotal clinical trials and recent real-world studies. The implant achieves IOP reductions comparable to topical prostaglandin analogs, with benefits for patient adherence and fewer common side effects. However, repeat administrations are associated with adverse effects such as endothelial cell loss, highlighting the need for optimized re-dosing schedules. Future research should explore its use in advanced glaucomas, cost-effectiveness, and combination with other IOP-lowering treatments. The bimatoprost intracameral implant represents a promising innovation in glaucoma therapy with potential for improved patient outcomes.Keywords: bimatoprost intracameral implant, glaucoma, intraocular pressure reduction, sustained-release therapy, primary open-angle glaucoma, ophthalmic drug delivery, patient adherence, prostaglandin analogs, endothelial cell safety, real-world evidence, cost-effectiveness, combination therapy in glaucomahttps://www.dovepress.com/bimatoprost-intracameral-implant-durysta-a-new-era-in-glaucoma-managem-peer-reviewed-fulltext-article-DDDTbimatoprost intracameral implantglaucomaintraocular pressure reductionsustained-release therapyprimary open-angle glaucomaophthalmic drug deliverypatient adherenceprostaglandin analogsendothelial cell safetyreal-world evidencecost-effectivenesscombination therapy in glaucoma |
| spellingShingle | Vagiakis I Papadopoulou EP Amaxilati E Tsiropoulos GN Konstas AG Panos GD Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation Drug Design, Development and Therapy bimatoprost intracameral implant glaucoma intraocular pressure reduction sustained-release therapy primary open-angle glaucoma ophthalmic drug delivery patient adherence prostaglandin analogs endothelial cell safety real-world evidence cost-effectiveness combination therapy in glaucoma |
| title | Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation |
| title_full | Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation |
| title_fullStr | Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation |
| title_full_unstemmed | Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation |
| title_short | Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation |
| title_sort | bimatoprost intracameral implant durysta reg a new era in glaucoma management through sustained release innovation |
| topic | bimatoprost intracameral implant glaucoma intraocular pressure reduction sustained-release therapy primary open-angle glaucoma ophthalmic drug delivery patient adherence prostaglandin analogs endothelial cell safety real-world evidence cost-effectiveness combination therapy in glaucoma |
| url | https://www.dovepress.com/bimatoprost-intracameral-implant-durysta-a-new-era-in-glaucoma-managem-peer-reviewed-fulltext-article-DDDT |
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