Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options
Background: Hypovitaminosis D can cause immunological irregularities in the development of immune thrombocytopenia. Objectives: To identify the frequency of low levels of 25-hydroxyvitamin D in children with Immune thrombocytopenia (ITP), and to assess the effect of the disease phase and type of...
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College of Medicine University of Baghdad
2024-12-01
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| Series: | مجلة كلية الطب |
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| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2401 |
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| author | Huda K. Abbas Basil O. Saleh Hassanain H. Ghali |
| author_facet | Huda K. Abbas Basil O. Saleh Hassanain H. Ghali |
| author_sort | Huda K. Abbas |
| collection | DOAJ |
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Background: Hypovitaminosis D can cause immunological irregularities in the development of immune thrombocytopenia.
Objectives: To identify the frequency of low levels of 25-hydroxyvitamin D in children with Immune thrombocytopenia (ITP), and to assess the effect of the disease phase and type of treatment on vitamin D level.
Methods: This case-control study was carried out on 88 children (63 had been diagnosed with immune thrombocytopenia and 25 healthy children as controls) during November 2023 and April 2024. The patients were sub-grouped according to global classification of vitamin D level into three groups: less than 10 ng/ml (n = 47), 10–20 ng/ml (n = 16), and 20-30 ng/ml (none of the patients or controls fell in this group). The cases were sub-classified according to their disease phase: Acute (n = 21), persistent (n = 24), and chronic (n = 18). The serum 25-hydroxyvitamin D level was measured using the enzyme-linked immunosorbent assay (ELISA) technique.
Results: Around 75% of ITP children had a serum 25-hydroxyvitamin D level of less than 10 ng/ml. The mean (± SEM) values of the serum 25-hydroxyvitamin D of the ITP children of acute (9.5±1.84 ng/ml) and chronic (8.0±1.13 ng/ml) phases were lower than those of controls (10.0±1.32 ng/ml, p > 0.05), but not significantly so. The mean values of 25 hydroxyvitamin D of ITP children were lower than those of the controls, irrespective of the type of treatment.
Conclusion: Vitamin D deficiency is prevalent among children with immune thrombocytopenia, particularly those in the chronic phase.
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| format | Article |
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| institution | Kabale University |
| issn | 0041-9419 2410-8057 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | College of Medicine University of Baghdad |
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| spelling | doaj-art-8fe8921451554266bb6aef87909ddc6f2025-01-19T12:24:08ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572024-12-0166410.32007/jfacmedbaghdad.6642401Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy OptionsHuda K. Abbas0https://orcid.org/0009-0008-2791-0043Basil O. Saleh1https://orcid.org/0009-0001-0053-5422Hassanain H. Ghali2https://orcid.org/0000-0003-0860-1479Department of Clinical Biochemistry, College of Medicine, University of Baghdad, Baghdad, Iraq.Department of Clinical Biochemistry, College of Medicine, University of Baghdad, Baghdad, Iraq.Department of Pediatric, College of Medicine, University of Baghdad, Baghdad, Iraq. Background: Hypovitaminosis D can cause immunological irregularities in the development of immune thrombocytopenia. Objectives: To identify the frequency of low levels of 25-hydroxyvitamin D in children with Immune thrombocytopenia (ITP), and to assess the effect of the disease phase and type of treatment on vitamin D level. Methods: This case-control study was carried out on 88 children (63 had been diagnosed with immune thrombocytopenia and 25 healthy children as controls) during November 2023 and April 2024. The patients were sub-grouped according to global classification of vitamin D level into three groups: less than 10 ng/ml (n = 47), 10–20 ng/ml (n = 16), and 20-30 ng/ml (none of the patients or controls fell in this group). The cases were sub-classified according to their disease phase: Acute (n = 21), persistent (n = 24), and chronic (n = 18). The serum 25-hydroxyvitamin D level was measured using the enzyme-linked immunosorbent assay (ELISA) technique. Results: Around 75% of ITP children had a serum 25-hydroxyvitamin D level of less than 10 ng/ml. The mean (± SEM) values of the serum 25-hydroxyvitamin D of the ITP children of acute (9.5±1.84 ng/ml) and chronic (8.0±1.13 ng/ml) phases were lower than those of controls (10.0±1.32 ng/ml, p > 0.05), but not significantly so. The mean values of 25 hydroxyvitamin D of ITP children were lower than those of the controls, irrespective of the type of treatment. Conclusion: Vitamin D deficiency is prevalent among children with immune thrombocytopenia, particularly those in the chronic phase. https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2401AutoimmuneImmune ThrombocytopenicPurpuraThrombocytopenic25-hydroxy vitamin D |
| spellingShingle | Huda K. Abbas Basil O. Saleh Hassanain H. Ghali Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options مجلة كلية الطب Autoimmune Immune Thrombocytopenic Purpura Thrombocytopenic 25-hydroxy vitamin D |
| title | Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options |
| title_full | Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options |
| title_fullStr | Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options |
| title_full_unstemmed | Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options |
| title_short | Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options |
| title_sort | frequency of 25 hydroxyvitamin d deficiency in pediatric patients with immune thrombocytopenia disease phase and therapy options |
| topic | Autoimmune Immune Thrombocytopenic Purpura Thrombocytopenic 25-hydroxy vitamin D |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2401 |
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