Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas
Background. Aproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1–T4, N0, M0) suffer recurrence and/or die. Method. In order to determine if tumor microvascular density (MVD) is a prognostic factor in CRC, samples from tumors of...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/679830 |
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| author | Rafael Uribarrena A Javier Ortego Javier Fuentes Nuria Raventós Pilar Parra Rafael Uribarrena E |
| author_facet | Rafael Uribarrena A Javier Ortego Javier Fuentes Nuria Raventós Pilar Parra Rafael Uribarrena E |
| author_sort | Rafael Uribarrena A |
| collection | DOAJ |
| description | Background. Aproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1–T4, N0, M0) suffer recurrence and/or die. Method. In order to determine if tumor microvascular density (MVD) is a prognostic factor in CRC, samples from tumors of 104 Dukes A-B CRC patients were retrospectively studied. Immunohistochemistry was performed for anti-CD34 antibody to visualize tumor vascularisation. MVD was expressed as the total number of vessels and as the percentage of microvascular area. We calculated MVD with a morphometry program and performed descriptive, bivariate, and survival statistics. Results. The mean number of vessels was 37.37/200x field, and the mean vascular area was the 3.972%. 30% of the patients with <37 vessels/field, and 21% of the patients with >37 vessels/field, experienced recurrence/death. The 35% of patients with <4% of vascular area died following recurrence, compared with 14% of patients with ≥4% of vascular area. These differences in % of vascular area were statistically significant. Conclusion. MVD expressed as the total number of vessels had no a statistically significant influence on the evolution of CRC. However, neoplasias with a greater % of vascular were associated to a better outcome. |
| format | Article |
| id | doaj-art-8fd31ecb236048e29cdd0f1b2b3d94a1 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-8fd31ecb236048e29cdd0f1b2b3d94a12025-02-03T06:15:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/679830679830Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal CarcinomasRafael Uribarrena A0Javier Ortego1Javier Fuentes2Nuria Raventós3Pilar Parra4Rafael Uribarrena E5Digestive Service, Hospital Universitario Miguel Servet, 50009, Zaragoza, SpainDepartment of Pathology, Hospital Clínico Universitario Lozano Blesa, 50009, Zaragoza, SpainDigestive Service, Hospital Universitario Miguel Servet, 50009, Zaragoza, SpainDepartment of Emergency, Hospital Universitario Miguel Servet, 50009, Zaragoza, SpainDepartment of Pathology, Hospital Clínico Universitario Lozano Blesa, 50009, Zaragoza, SpainDigestive Service, Hospital Universitario Miguel Servet, 50009, Zaragoza, SpainBackground. Aproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1–T4, N0, M0) suffer recurrence and/or die. Method. In order to determine if tumor microvascular density (MVD) is a prognostic factor in CRC, samples from tumors of 104 Dukes A-B CRC patients were retrospectively studied. Immunohistochemistry was performed for anti-CD34 antibody to visualize tumor vascularisation. MVD was expressed as the total number of vessels and as the percentage of microvascular area. We calculated MVD with a morphometry program and performed descriptive, bivariate, and survival statistics. Results. The mean number of vessels was 37.37/200x field, and the mean vascular area was the 3.972%. 30% of the patients with <37 vessels/field, and 21% of the patients with >37 vessels/field, experienced recurrence/death. The 35% of patients with <4% of vascular area died following recurrence, compared with 14% of patients with ≥4% of vascular area. These differences in % of vascular area were statistically significant. Conclusion. MVD expressed as the total number of vessels had no a statistically significant influence on the evolution of CRC. However, neoplasias with a greater % of vascular were associated to a better outcome.http://dx.doi.org/10.1155/2009/679830 |
| spellingShingle | Rafael Uribarrena A Javier Ortego Javier Fuentes Nuria Raventós Pilar Parra Rafael Uribarrena E Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas Gastroenterology Research and Practice |
| title | Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas |
| title_full | Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas |
| title_fullStr | Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas |
| title_full_unstemmed | Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas |
| title_short | Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas |
| title_sort | prognostic value of microvascular density in dukes a and b t1 t4 n0 m0 colorectal carcinomas |
| url | http://dx.doi.org/10.1155/2009/679830 |
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