Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty
Pubertal onset is characterized by reactivation of the hypothalamic-pituitary-gonadal axis resulting in pulsatile gonadotropin secretion and subsequent sex steroid production. Accurate measurements of the gonadotropins and sex steroids are essential to ensure timely diagnosis of precocious puberty,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1504874/full |
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| author | Kanthi Bangalore Krishna Luigi Garibaldi |
| author_facet | Kanthi Bangalore Krishna Luigi Garibaldi |
| author_sort | Kanthi Bangalore Krishna |
| collection | DOAJ |
| description | Pubertal onset is characterized by reactivation of the hypothalamic-pituitary-gonadal axis resulting in pulsatile gonadotropin secretion and subsequent sex steroid production. Accurate measurements of the gonadotropins and sex steroids are essential to ensure timely diagnosis of precocious puberty, so as to determine optimal management. This review summarizes the available laboratory testing for the diagnosis of puberty, discussing the different assays used while reviewing the limitations of such testing. |
| format | Article |
| id | doaj-art-8fc483d1487245bab6080688fe23ffcf |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-8fc483d1487245bab6080688fe23ffcf2025-01-22T10:27:15ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.15048741504874Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious pubertyKanthi Bangalore KrishnaLuigi GaribaldiPubertal onset is characterized by reactivation of the hypothalamic-pituitary-gonadal axis resulting in pulsatile gonadotropin secretion and subsequent sex steroid production. Accurate measurements of the gonadotropins and sex steroids are essential to ensure timely diagnosis of precocious puberty, so as to determine optimal management. This review summarizes the available laboratory testing for the diagnosis of puberty, discussing the different assays used while reviewing the limitations of such testing.https://www.frontiersin.org/articles/10.3389/fped.2024.1504874/fullpubertyprecocious pubertyGnRHaLHFSH |
| spellingShingle | Kanthi Bangalore Krishna Luigi Garibaldi Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty Frontiers in Pediatrics puberty precocious puberty GnRHa LH FSH |
| title | Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty |
| title_full | Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty |
| title_fullStr | Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty |
| title_full_unstemmed | Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty |
| title_short | Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty |
| title_sort | critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty |
| topic | puberty precocious puberty GnRHa LH FSH |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1504874/full |
| work_keys_str_mv | AT kanthibangalorekrishna criticalappraisalofdiagnosticlaboratorytestsintheevaluationofcentralprecociouspuberty AT luigigaribaldi criticalappraisalofdiagnosticlaboratorytestsintheevaluationofcentralprecociouspuberty |