Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study
Cardiac abnormalities are the most common and deadly comorbidities of acromegaly. Assessments using cardiac magnetic resonance (CMR) imaging in acromegaly patients are rare. We aimed to evaluate the frequencies of left ventricular hypertrophy (LVH), interventricular septum hypertrophy (IVSH), LV sys...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/2018464 |
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| author | Xiaopeng Guo Jian Cao Peijun Liu Yihan Cao Xiao Li Lu Gao Zihao Wang Ligang Fang Zhengyu Jin Yining Wang Bing Xing |
| author_facet | Xiaopeng Guo Jian Cao Peijun Liu Yihan Cao Xiao Li Lu Gao Zihao Wang Ligang Fang Zhengyu Jin Yining Wang Bing Xing |
| author_sort | Xiaopeng Guo |
| collection | DOAJ |
| description | Cardiac abnormalities are the most common and deadly comorbidities of acromegaly. Assessments using cardiac magnetic resonance (CMR) imaging in acromegaly patients are rare. We aimed to evaluate the frequencies of left ventricular hypertrophy (LVH), interventricular septum hypertrophy (IVSH), LV systolic dysfunction (LVSD), right ventricular systolic dysfunction (RVSD), and myocardial fibrosis (MCF) and detailed quantitative parameters in acromegaly patients using CMR and analyze their correlations with clinical features. Sixty-one patients were enrolled in this study. The rates of LVH, IVSH, LVSD, RVSD, and MCF were 26.2%, 27.9%, 8.2%, 9.8%, and 14.8%, respectively. The average LV mass, LV mass index, IVS thickness, LV and RV free wall thickness, and LV and RV ejection fractions were 114.4 g, 60.0 g/m2, 9.6 mm, 7.2 mm, 2.9 mm, 59.9%, and 56.6%, respectively. The LV mass index was larger (68.9 ± 26.0 vs. 48.8 ± 10.6 g/m2), the IVS was thicker (10.3 ± 2.8 vs. 8.8 ± 1.8 mm), and the LV (57.6 ± 12.3% vs. 62.8 ± 4.8%) and RV ejection fractions (54.6 ± 8.7% vs. 59.2 ± 5.9%) were lower in male patients than in female patients (all p<0.05). Age, body mass index (BMI), disease duration, and hypertension were associated with cardiac abnormalities (all p<0.05). In conclusion, structural and functional cardiac abnormalities can be comprehensively evaluated by CMR in acromegaly patients. Gender greatly affects the presence of cardiac abnormalities. Age, BMI, disease duration, and hypertension but not GH or IGF-1 levels are associated clinical factors. |
| format | Article |
| id | doaj-art-8fb764b5f406420ead0d32449f6f4de5 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8fb764b5f406420ead0d32449f6f4de52025-02-03T06:43:45ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/20184642018464Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance StudyXiaopeng Guo0Jian Cao1Peijun Liu2Yihan Cao3Xiao Li4Lu Gao5Zihao Wang6Ligang Fang7Zhengyu Jin8Yining Wang9Bing Xing10Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaCardiac abnormalities are the most common and deadly comorbidities of acromegaly. Assessments using cardiac magnetic resonance (CMR) imaging in acromegaly patients are rare. We aimed to evaluate the frequencies of left ventricular hypertrophy (LVH), interventricular septum hypertrophy (IVSH), LV systolic dysfunction (LVSD), right ventricular systolic dysfunction (RVSD), and myocardial fibrosis (MCF) and detailed quantitative parameters in acromegaly patients using CMR and analyze their correlations with clinical features. Sixty-one patients were enrolled in this study. The rates of LVH, IVSH, LVSD, RVSD, and MCF were 26.2%, 27.9%, 8.2%, 9.8%, and 14.8%, respectively. The average LV mass, LV mass index, IVS thickness, LV and RV free wall thickness, and LV and RV ejection fractions were 114.4 g, 60.0 g/m2, 9.6 mm, 7.2 mm, 2.9 mm, 59.9%, and 56.6%, respectively. The LV mass index was larger (68.9 ± 26.0 vs. 48.8 ± 10.6 g/m2), the IVS was thicker (10.3 ± 2.8 vs. 8.8 ± 1.8 mm), and the LV (57.6 ± 12.3% vs. 62.8 ± 4.8%) and RV ejection fractions (54.6 ± 8.7% vs. 59.2 ± 5.9%) were lower in male patients than in female patients (all p<0.05). Age, body mass index (BMI), disease duration, and hypertension were associated with cardiac abnormalities (all p<0.05). In conclusion, structural and functional cardiac abnormalities can be comprehensively evaluated by CMR in acromegaly patients. Gender greatly affects the presence of cardiac abnormalities. Age, BMI, disease duration, and hypertension but not GH or IGF-1 levels are associated clinical factors.http://dx.doi.org/10.1155/2020/2018464 |
| spellingShingle | Xiaopeng Guo Jian Cao Peijun Liu Yihan Cao Xiao Li Lu Gao Zihao Wang Ligang Fang Zhengyu Jin Yining Wang Bing Xing Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study International Journal of Endocrinology |
| title | Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study |
| title_full | Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study |
| title_fullStr | Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study |
| title_full_unstemmed | Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study |
| title_short | Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study |
| title_sort | cardiac abnormalities in acromegaly patients a cardiac magnetic resonance study |
| url | http://dx.doi.org/10.1155/2020/2018464 |
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