Fast real-time monitoring of entacapone crystallization and characterization of polymorphs via Raman spectroscopy, statistics and SWAXS

Fast real-time monitoring of entacapone crystallization and characterization of polymorphs via Raman spectroscopy, statistics and SWAXS

Crystallization of the drug entacapone from binary solvent mixtures was monitored in situ using a Raman optical probe. The recorded Raman spectra and statistical analysis, which included the principal components method and indirect hard modeling made it possible to estimate the starting point of cry...

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Bibliographic Details
Main Authors: Jednačak Tomislav, Hodzic Aden, Scheibelhofer Otto, Marijan Marijan, Khinast Johannes G., Novak Predrag
Format: Article
Language:English
Published: Sciendo 2014-03-01
Series:Acta Pharmaceutica
Subjects:
entacapone
in-line crystallization monitoring
multivariate analysis
polymorphism
Raman spectroscopy
SWAXS
Online Access:http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0009/acph-2014-0009.xml?format=INT
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http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0009/acph-2014-0009.xml?format=INT

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