Identification of biomarkers associated with exhausted CD8 + T cells in the tumor microenvironment of intrahepatic cholangiocarcinoma based on Mendelian randomization and bioinformatics analysis

Identification of biomarkers associated with exhausted CD8 + T cells in the tumor microenvironment of intrahepatic cholangiocarcinoma based on Mendelian randomization and bioinformatics analysis

Abstract Intrahepatic cholangiocarcinoma (iCCA) represents a growing health concern due to its increasing incidence and poor prognosis, highlighting the urgent need for biomarkers and therapeutic targets. This study utilized BayesPrism deconvolution, Weighted Gene Co-expression Network Analysis (WGC...

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Bibliographic Details
Main Authors: LiuXing Feng, Quan Yuan, Hao Yu, RongJie Ye, ZhenHao Xie, JiaHuan Xu, XiuDong Li, ShuangJia Wang
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Intrahepatic cholangiocarcinoma
Exhausted CD8 + T cells
Immunotherapy
Mendelian randomization
Online Access:https://doi.org/10.1007/s12672-025-02970-w
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