The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study
BackgroundPhysical activity (PA) protects against cardiovascular disease. However, previous research has shown that high PA is associated with an increased carotid intima-media-thickness (cIMT), an independent predictor for future cardiovascular disease. Our aim was to further investigate this unexp...
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Frontiers Media S.A.
2025-02-01
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| author | Bernhard Winder Bernhard Winder Bernhard Winder Sophia J. Kiechl Sophia J. Kiechl Benoît Bernar Benoît Bernar Nina Gande Anna Staudt Anna K. Stock Anna K. Stock Christoph Hochmayr Ralf Geiger Andrea Griesmacher Stefan Kiechl Stefan Kiechl Ursula Kiechl-Kohlendorfer Michael Knoflach Michael Knoflach the Early Vascular Ageing (EVA)-Tyrol Study Group Carmen Reiter Christina Schreiner Julia Klingenschmid Julia Marxer Martina Kothmayer Maximilian Pircher Manuela Bock-Bartl Mandy Asare Maximilian Bohl Raimund Pechlaner |
| author_facet | Bernhard Winder Bernhard Winder Bernhard Winder Sophia J. Kiechl Sophia J. Kiechl Benoît Bernar Benoît Bernar Nina Gande Anna Staudt Anna K. Stock Anna K. Stock Christoph Hochmayr Ralf Geiger Andrea Griesmacher Stefan Kiechl Stefan Kiechl Ursula Kiechl-Kohlendorfer Michael Knoflach Michael Knoflach the Early Vascular Ageing (EVA)-Tyrol Study Group Carmen Reiter Christina Schreiner Julia Klingenschmid Julia Marxer Martina Kothmayer Maximilian Pircher Manuela Bock-Bartl Mandy Asare Maximilian Bohl Raimund Pechlaner |
| author_sort | Bernhard Winder |
| collection | DOAJ |
| description | BackgroundPhysical activity (PA) protects against cardiovascular disease. However, previous research has shown that high PA is associated with an increased carotid intima-media-thickness (cIMT), an independent predictor for future cardiovascular disease. Our aim was to further investigate this unexpected association with two different measurement methods of PA and two established markers for Early Vascular Ageing: cIMT and carotid-femoral pulse-wave velocity (cfPWV).MethodsThe community-based Early Vascular Ageing-Tyrol cohort study included adolescents in western Austria and northern Italy. Medical examinations included anthropometric measurements, fasting blood analysis, a physician guided interview to assess lifestyle factors, measurement of cIMT and cfPWV. PA was rated by an in-person interview on the basis of average minutes of moderate- or vigorous sports per day and by the Baecke questionnaire expressed as Baecke score (BS).ResultsComplete data set was available for 1,001 adolescents with a mean age of 17.8 years (standard deviation ±0.9 years). 558 (55.7%) of participants were female. cIMT was positively associated with both measures of PA in univariate (minutes sports per day: p < 0.001; BS: p < 0.001) as well as multivariable analysis adjusting for established cardiovascular risk factors (minutes sports per day: p = 0.001; BS: p = 0.002). Using cfPWV in a multivariate model an inverse correlation with the BS (p = 0.023) was observed, but not for minutes sports per day (p = 0.554).ConclusionIn our large community-based cohort of adolescents, PA was associated with an increased cIMT but shows a trend towards lower aortic stiffness measured by cfPWV. We hypothesize that the association of PA with increased cIMT is not caused by early atherosclerotic vessel wall changes but is rather a physiologic adaptive process of the vessel wall.
Trial Registration NumberThe EVA-Tyrol Study has been registered at clinicaltrials.gov under NCT03929692 since April 29, 2019. |
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| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-8f9ecd798cd345fb9128e467af4042a82025-02-06T07:09:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-02-011310.3389/fped.2025.15271321527132The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort studyBernhard Winder0Bernhard Winder1Bernhard Winder2Sophia J. Kiechl3Sophia J. Kiechl4Benoît Bernar5Benoît Bernar6Nina Gande7Anna Staudt8Anna K. Stock9Anna K. Stock10Christoph Hochmayr11Ralf Geiger12Andrea Griesmacher13Stefan Kiechl14Stefan Kiechl15Ursula Kiechl-Kohlendorfer16Michael Knoflach17Michael Knoflach18the Early Vascular Ageing (EVA)-Tyrol Study GroupCarmen ReiterChristina Schreiner Julia KlingenschmidJulia MarxerMartina KothmayerMaximilian PircherManuela Bock-BartlMandy AsareMaximilian BohlRaimund PechlanerDepartment of Vascular Surgery, Academic Teaching Hospital Feldkirch, Feldkirch, AustriaDepartment of Pediatrics II, Medical University of Innsbruck, Innsbruck, AustriaVASCage, Centre on Clinical Stroke Research, Innsbruck, AustriaVASCage, Centre on Clinical Stroke Research, Innsbruck, AustriaDepartment of Neurology, Hochzirl Hospital, Zirl, AustriaDepartment of Pediatrics I, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Anesthesiology and Intensive Care, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics II, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics II, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics III, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics II, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics III, Medical University of Innsbruck, Innsbruck, AustriaCentral Institute of Clinical Chemistry and Laboratory Medicine (ZIMCL), Medical University of Innsbruck, Innsbruck, AustriaVASCage, Centre on Clinical Stroke Research, Innsbruck, Austria0Department of Neurology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Pediatrics II, Medical University of Innsbruck, Innsbruck, AustriaVASCage, Centre on Clinical Stroke Research, Innsbruck, Austria0Department of Neurology, Medical University of Innsbruck, Innsbruck, AustriaBackgroundPhysical activity (PA) protects against cardiovascular disease. However, previous research has shown that high PA is associated with an increased carotid intima-media-thickness (cIMT), an independent predictor for future cardiovascular disease. Our aim was to further investigate this unexpected association with two different measurement methods of PA and two established markers for Early Vascular Ageing: cIMT and carotid-femoral pulse-wave velocity (cfPWV).MethodsThe community-based Early Vascular Ageing-Tyrol cohort study included adolescents in western Austria and northern Italy. Medical examinations included anthropometric measurements, fasting blood analysis, a physician guided interview to assess lifestyle factors, measurement of cIMT and cfPWV. PA was rated by an in-person interview on the basis of average minutes of moderate- or vigorous sports per day and by the Baecke questionnaire expressed as Baecke score (BS).ResultsComplete data set was available for 1,001 adolescents with a mean age of 17.8 years (standard deviation ±0.9 years). 558 (55.7%) of participants were female. cIMT was positively associated with both measures of PA in univariate (minutes sports per day: p < 0.001; BS: p < 0.001) as well as multivariable analysis adjusting for established cardiovascular risk factors (minutes sports per day: p = 0.001; BS: p = 0.002). Using cfPWV in a multivariate model an inverse correlation with the BS (p = 0.023) was observed, but not for minutes sports per day (p = 0.554).ConclusionIn our large community-based cohort of adolescents, PA was associated with an increased cIMT but shows a trend towards lower aortic stiffness measured by cfPWV. We hypothesize that the association of PA with increased cIMT is not caused by early atherosclerotic vessel wall changes but is rather a physiologic adaptive process of the vessel wall. Trial Registration NumberThe EVA-Tyrol Study has been registered at clinicaltrials.gov under NCT03929692 since April 29, 2019.https://www.frontiersin.org/articles/10.3389/fped.2025.1527132/fullphysical activityBaecke questionnairecarotid intima-media-thicknesscardiovascular risk factorsearly vascular aging |
| spellingShingle | Bernhard Winder Bernhard Winder Bernhard Winder Sophia J. Kiechl Sophia J. Kiechl Benoît Bernar Benoît Bernar Nina Gande Anna Staudt Anna K. Stock Anna K. Stock Christoph Hochmayr Ralf Geiger Andrea Griesmacher Stefan Kiechl Stefan Kiechl Ursula Kiechl-Kohlendorfer Michael Knoflach Michael Knoflach the Early Vascular Ageing (EVA)-Tyrol Study Group Carmen Reiter Christina Schreiner Julia Klingenschmid Julia Marxer Martina Kothmayer Maximilian Pircher Manuela Bock-Bartl Mandy Asare Maximilian Bohl Raimund Pechlaner The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study Frontiers in Pediatrics physical activity Baecke questionnaire carotid intima-media-thickness cardiovascular risk factors early vascular aging |
| title | The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study |
| title_full | The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study |
| title_fullStr | The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study |
| title_full_unstemmed | The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study |
| title_short | The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study |
| title_sort | association of physical activity and carotid intima media thickness in adolescents data of the prospective early vascular ageing tyrol cohort study |
| topic | physical activity Baecke questionnaire carotid intima-media-thickness cardiovascular risk factors early vascular aging |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1527132/full |
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