Learning patterns of HIV-1 resistance to broadly neutralizing antibodies with reduced subtype bias using multi-task learning.
The ability to predict HIV-1 resistance to broadly neutralizing antibodies (bnAbs) will increase bnAb therapeutic benefits. Machine learning is a powerful approach for such prediction. One challenge is that some HIV-1 subtypes in currently available training datasets are underrepresented, which like...
Saved in:
| Main Authors: | Aime Bienfait Igiraneza, Panagiota Zacharopoulou, Robert Hinch, Chris Wymant, Lucie Abeler-Dörner, John Frater, Christophe Fraser |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-11-01
|
| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1012618 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Distinct neutralization sensitivity between adult and infant transmitted/founder HIV-1 subtype C viruses to broadly neutralizing monoclonal antibodies.
by: Bongiwe Ndlovu, et al.
Published: (2025-06-01) -
Defining criteria for broadly neutralizing HIV antibodies
by: Elizabeth-Sharon David-Fung, et al.
Published: (2025-07-01) -
Non-cognate ligands of hepatitis C virus envelope broadly neutralizing antibodies induce virus-neutralizing sera in mice
by: Stephen Ian Walimbwa, et al.
Published: (2025-07-01) -
Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention
by: Juan C Becerra, et al.
Published: (2024-07-01) -
Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C.
by: Nika Strokappe, et al.
Published: (2012-01-01)