Intraductal Papillary Neoplasms of the Bile Duct
Intraductal papillary neoplasm of the bile duct (IPNB) is a rare variant of bile duct tumors characterized by papillary growth within the bile duct lumen and is regarded as a biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas. IPNBs display a spectrum of premalignant lesi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2014/459091 |
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| author | Masayuki Ohtsuka Hiroaki Shimizu Atsushi Kato Hideyuki Yoshitomi Katsunori Furukawa Toshio Tsuyuguchi Yuji Sakai Osamu Yokosuka Masaru Miyazaki |
| author_facet | Masayuki Ohtsuka Hiroaki Shimizu Atsushi Kato Hideyuki Yoshitomi Katsunori Furukawa Toshio Tsuyuguchi Yuji Sakai Osamu Yokosuka Masaru Miyazaki |
| author_sort | Masayuki Ohtsuka |
| collection | DOAJ |
| description | Intraductal papillary neoplasm of the bile duct (IPNB) is a rare variant of bile duct tumors characterized by papillary growth within the bile duct lumen and is regarded as a biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas. IPNBs display a spectrum of premalignant lesion towards invasive cholangiocarcinoma. The most common radiologic findings for IPNB are bile duct dilatation and intraductal masses. The major treatment of IPNB is surgical resection. Ultrasonography, computed tomography, magnetic resonance image, and cholangiography are usually performed to assess tumor location and extension. Cholangioscopy can confirm the histology and assess the extent of the tumor including superficial spreading along the biliary epithelium. However, pathologic diagnosis by preoperative biopsy cannot always reflect the maximum degree of atypia, because IPNBs are often composed of varying degrees of cytoarchitectural atypia. IPNBs are microscopically classified into four epithelial subtypes, such as pancreatobiliary, intestinal, gastric, and oncocytic types. Most cases of IPNB are IPN with high-grade intraepithelial neoplasia or with an associated invasive carcinoma. The histologic types of invasive lesions are either tubular adenocarcinoma or mucinous carcinoma. Although several authors have investigated molecular genetic changes during the development and progression of IPNB, these are still poorly characterized and controversial. |
| format | Article |
| id | doaj-art-8f937f5614e64365b903ecc309fd4950 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-8f937f5614e64365b903ecc309fd49502025-02-03T01:01:02ZengWileyInternational Journal of Hepatology2090-34482090-34562014-01-01201410.1155/2014/459091459091Intraductal Papillary Neoplasms of the Bile DuctMasayuki Ohtsuka0Hiroaki Shimizu1Atsushi Kato2Hideyuki Yoshitomi3Katsunori Furukawa4Toshio Tsuyuguchi5Yuji Sakai6Osamu Yokosuka7Masaru Miyazaki8Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoh-ku, Chiba 260-8670, JapanDepartment of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoh-ku, Chiba 260-8670, JapanDepartment of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoh-ku, Chiba 260-8670, JapanDepartment of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoh-ku, Chiba 260-8670, JapanDepartment of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoh-ku, Chiba 260-8670, JapanDepartment of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoh-ku, Chiba 260-8670, JapanIntraductal papillary neoplasm of the bile duct (IPNB) is a rare variant of bile duct tumors characterized by papillary growth within the bile duct lumen and is regarded as a biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas. IPNBs display a spectrum of premalignant lesion towards invasive cholangiocarcinoma. The most common radiologic findings for IPNB are bile duct dilatation and intraductal masses. The major treatment of IPNB is surgical resection. Ultrasonography, computed tomography, magnetic resonance image, and cholangiography are usually performed to assess tumor location and extension. Cholangioscopy can confirm the histology and assess the extent of the tumor including superficial spreading along the biliary epithelium. However, pathologic diagnosis by preoperative biopsy cannot always reflect the maximum degree of atypia, because IPNBs are often composed of varying degrees of cytoarchitectural atypia. IPNBs are microscopically classified into four epithelial subtypes, such as pancreatobiliary, intestinal, gastric, and oncocytic types. Most cases of IPNB are IPN with high-grade intraepithelial neoplasia or with an associated invasive carcinoma. The histologic types of invasive lesions are either tubular adenocarcinoma or mucinous carcinoma. Although several authors have investigated molecular genetic changes during the development and progression of IPNB, these are still poorly characterized and controversial.http://dx.doi.org/10.1155/2014/459091 |
| spellingShingle | Masayuki Ohtsuka Hiroaki Shimizu Atsushi Kato Hideyuki Yoshitomi Katsunori Furukawa Toshio Tsuyuguchi Yuji Sakai Osamu Yokosuka Masaru Miyazaki Intraductal Papillary Neoplasms of the Bile Duct International Journal of Hepatology |
| title | Intraductal Papillary Neoplasms of the Bile Duct |
| title_full | Intraductal Papillary Neoplasms of the Bile Duct |
| title_fullStr | Intraductal Papillary Neoplasms of the Bile Duct |
| title_full_unstemmed | Intraductal Papillary Neoplasms of the Bile Duct |
| title_short | Intraductal Papillary Neoplasms of the Bile Duct |
| title_sort | intraductal papillary neoplasms of the bile duct |
| url | http://dx.doi.org/10.1155/2014/459091 |
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