The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model
Several devices and medications have been used to address poststroke spasticity. Yet, spasticity’s impact on outcomes remains controversial. Using data from a cohort of 460 ischemic stroke patients, we previously published a validated multivariable regression model for predicting 3-month modified Ra...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2014/696089 |
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| author | S. R. Belagaje C. Lindsell C. J. Moomaw K. Alwell M. L. Flaherty D. Woo K. Dunning P. Khatri O. Adeoye D. Kleindorfer J. Broderick B. Kissela |
| author_facet | S. R. Belagaje C. Lindsell C. J. Moomaw K. Alwell M. L. Flaherty D. Woo K. Dunning P. Khatri O. Adeoye D. Kleindorfer J. Broderick B. Kissela |
| author_sort | S. R. Belagaje |
| collection | DOAJ |
| description | Several devices and medications have been used to address poststroke spasticity. Yet, spasticity’s impact on outcomes remains controversial. Using data from a cohort of 460 ischemic stroke patients, we previously published a validated multivariable regression model for predicting 3-month modified Rankin Score (mRS) as an indicator of functional outcome. Here, we tested whether including spasticity improved model fit and estimated the effect spasticity had on the outcome. Spasticity was defined by a positive response to the question “Did you have spasticity following your stroke?” on direct interview at 3 months from stroke onset. Patients who had expired by 90 days (n=30) or did not have spasticity data available (n=102) were excluded. Spasticity affected the 3-month functional status (β=0.420, 95 CI=0.194 to 0.645) after accounting for age, diabetes, leukoaraiosis, and retrospective NIHSS. Using spasticity as a covariable, the model’s R2 changed from 0.599 to 0.622. In our model, the presence of spasticity in the cohort was associated with a worsened 3-month mRS by an average of 0.4 after adjusting for known covariables. This significant adverse effect on functional outcomes adds predictive value beyond previously established factors. |
| format | Article |
| id | doaj-art-8f7ec48676c84c2a82c437e9753ea32f |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-8f7ec48676c84c2a82c437e9753ea32f2025-02-03T01:06:21ZengWileyStroke Research and Treatment2090-81052042-00562014-01-01201410.1155/2014/696089696089The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based ModelS. R. Belagaje0C. Lindsell1C. J. Moomaw2K. Alwell3M. L. Flaherty4D. Woo5K. Dunning6P. Khatri7O. Adeoye8D. Kleindorfer9J. Broderick10B. Kissela11Departments of Neurology and Rehabilitation Medicine, Emory University School of Medicine, 80 Jesse Hill Jr. Drive SE, Atlanta, GA 30303, USADepartment of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45219, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Rehabilitation Sciences, University of Cincinnati, Cincinnati, OH 45219, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45219, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USASeveral devices and medications have been used to address poststroke spasticity. Yet, spasticity’s impact on outcomes remains controversial. Using data from a cohort of 460 ischemic stroke patients, we previously published a validated multivariable regression model for predicting 3-month modified Rankin Score (mRS) as an indicator of functional outcome. Here, we tested whether including spasticity improved model fit and estimated the effect spasticity had on the outcome. Spasticity was defined by a positive response to the question “Did you have spasticity following your stroke?” on direct interview at 3 months from stroke onset. Patients who had expired by 90 days (n=30) or did not have spasticity data available (n=102) were excluded. Spasticity affected the 3-month functional status (β=0.420, 95 CI=0.194 to 0.645) after accounting for age, diabetes, leukoaraiosis, and retrospective NIHSS. Using spasticity as a covariable, the model’s R2 changed from 0.599 to 0.622. In our model, the presence of spasticity in the cohort was associated with a worsened 3-month mRS by an average of 0.4 after adjusting for known covariables. This significant adverse effect on functional outcomes adds predictive value beyond previously established factors.http://dx.doi.org/10.1155/2014/696089 |
| spellingShingle | S. R. Belagaje C. Lindsell C. J. Moomaw K. Alwell M. L. Flaherty D. Woo K. Dunning P. Khatri O. Adeoye D. Kleindorfer J. Broderick B. Kissela The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model Stroke Research and Treatment |
| title | The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model |
| title_full | The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model |
| title_fullStr | The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model |
| title_full_unstemmed | The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model |
| title_short | The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model |
| title_sort | adverse effect of spasticity on 3 month poststroke outcome using a population based model |
| url | http://dx.doi.org/10.1155/2014/696089 |
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