Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

Abstract Background Genetic studies have associated thousands of enhancers with breast cancer (BC). However, the vast majority have not been functionally characterized. Thus, it remains unclear how BC-associated enhancers contribute to cancer. Results Here, we perform single-cell CRISPRi screens of...

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Bibliographic Details
Main Authors: Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Genome Biology
Subjects:
Enhancers
Functional genomics
Cancer genomics
Regulatory networks
Breast cancer
Single-cell
Online Access:https://doi.org/10.1186/s13059-025-03474-0
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