Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related Factors
<i>Background and Objectives</i>: We aimed to evaluate the outcome of systemic lupus erythematosus (SLE) patients undergoing hemodialysis (HD) by comparing the survival among HD patients with SLE, diabetes mellitus (DM), or other diseases in the Korean population. We also analyzed the fa...
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MDPI AG
2025-01-01
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| author | Hwajeong Lee Seok-Hui Kang |
| author_facet | Hwajeong Lee Seok-Hui Kang |
| author_sort | Hwajeong Lee |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: We aimed to evaluate the outcome of systemic lupus erythematosus (SLE) patients undergoing hemodialysis (HD) by comparing the survival among HD patients with SLE, diabetes mellitus (DM), or other diseases in the Korean population. We also analyzed the factors affecting the survival of SLE patients undergoing HD. <i>Materials and Methods</i>: This retrospective study analyzed laboratory data from a national HD quality assessment program and claims data. The programs included maintenance HD patients aged ≥18 years. The patients were divided into three groups according to underlying comorbidities as follows: SLE (<i>n</i> = 569), DM (<i>n</i> = 24,665), and others (<i>n</i> = 31,004). <i>Results</i>: The Kaplan–Meier curve showed that the SLE group had better survival than the other two groups. Multivariate analysis showed that the hazard ratios were 0.89 (<i>p</i> = 0.334) in the others group and 1.32 (<i>p</i> = 0.015) in the DM group compared to those in the SLE group. In the SLE group, age, the Charlson Comorbidity Index (CCI) score, hemoglobin, serum creatinine levels, and systolic blood pressure (SBP) were associated with patient survival. <i>Conclusions</i>: This study showed that HD patients with SLE had better patient survival than those with DM and comparable survival with those with other diseases, except SLE or DM. In addition, age, CCI score, hemoglobin, serum creatinine level, and SBP were associated with survival in HD patients with SLE. |
| format | Article |
| id | doaj-art-8f795832dc40456c87d9aace11724be1 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-8f795832dc40456c87d9aace11724be12025-01-24T13:40:53ZengMDPI AGMedicina1010-660X1648-91442025-01-0161115510.3390/medicina61010155Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related FactorsHwajeong Lee0Seok-Hui Kang1Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu 42472, Republic of KoreaDivision of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea<i>Background and Objectives</i>: We aimed to evaluate the outcome of systemic lupus erythematosus (SLE) patients undergoing hemodialysis (HD) by comparing the survival among HD patients with SLE, diabetes mellitus (DM), or other diseases in the Korean population. We also analyzed the factors affecting the survival of SLE patients undergoing HD. <i>Materials and Methods</i>: This retrospective study analyzed laboratory data from a national HD quality assessment program and claims data. The programs included maintenance HD patients aged ≥18 years. The patients were divided into three groups according to underlying comorbidities as follows: SLE (<i>n</i> = 569), DM (<i>n</i> = 24,665), and others (<i>n</i> = 31,004). <i>Results</i>: The Kaplan–Meier curve showed that the SLE group had better survival than the other two groups. Multivariate analysis showed that the hazard ratios were 0.89 (<i>p</i> = 0.334) in the others group and 1.32 (<i>p</i> = 0.015) in the DM group compared to those in the SLE group. In the SLE group, age, the Charlson Comorbidity Index (CCI) score, hemoglobin, serum creatinine levels, and systolic blood pressure (SBP) were associated with patient survival. <i>Conclusions</i>: This study showed that HD patients with SLE had better patient survival than those with DM and comparable survival with those with other diseases, except SLE or DM. In addition, age, CCI score, hemoglobin, serum creatinine level, and SBP were associated with survival in HD patients with SLE.https://www.mdpi.com/1648-9144/61/1/155systemic lupus erythematosushemodialysismortality |
| spellingShingle | Hwajeong Lee Seok-Hui Kang Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related Factors Medicina systemic lupus erythematosus hemodialysis mortality |
| title | Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related Factors |
| title_full | Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related Factors |
| title_fullStr | Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related Factors |
| title_full_unstemmed | Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related Factors |
| title_short | Systemic Lupus Erythematosus in Hemodialysis: Survival Comparison and Mortality-Related Factors |
| title_sort | systemic lupus erythematosus in hemodialysis survival comparison and mortality related factors |
| topic | systemic lupus erythematosus hemodialysis mortality |
| url | https://www.mdpi.com/1648-9144/61/1/155 |
| work_keys_str_mv | AT hwajeonglee systemiclupuserythematosusinhemodialysissurvivalcomparisonandmortalityrelatedfactors AT seokhuikang systemiclupuserythematosusinhemodialysissurvivalcomparisonandmortalityrelatedfactors |